BDBM27167 1H-indol-1-yl tertiary amine, 11::{[2-chloro-3-(trifluoromethyl)phenyl]methyl}[3-({4,6-dimethyl-1H-pyrazolo[3,4-b]pyridin-3-yl}oxy)propyl](2,2-diphenylethyl)amine
SMILES: Cc1cc(C)c2c(OCCCN(CC(c3ccccc3)c3ccccc3)Cc3cccc(c3Cl)C(F)(F)F)n[nH]c2n1
InChI Key: InChIKey=UIUZIKMYVPKHET-UHFFFAOYSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Oxysterols receptor LXR-beta (Homo sapiens (Human)) | BDBM27167 (1H-indol-1-yl tertiary amine, 11 | {[2-chloro-3-(t...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 510 | n/a | n/a | 7.5 | 22 |
GSK | Assay Description The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding... | Bioorg Med Chem Lett 19: 1097-100 (2009) Article DOI: 10.1016/j.bmcl.2009.01.004 BindingDB Entry DOI: 10.7270/Q28W3BMD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oxysterols receptor LXR-alpha (Homo sapiens (Human)) | BDBM27167 (1H-indol-1-yl tertiary amine, 11 | {[2-chloro-3-(t...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >3.00E+3 | n/a | n/a | 7.5 | 22 |
GSK | Assay Description The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding... | Bioorg Med Chem Lett 19: 1097-100 (2009) Article DOI: 10.1016/j.bmcl.2009.01.004 BindingDB Entry DOI: 10.7270/Q28W3BMD | |||||||||||
More data for this Ligand-Target Pair |