BDBM290416 (3R,4S)-3-amino-1-(2-(biphenyl-4-ylamino)ethyl)-4-(3- boronopropyl)pyrrolidine-3-carboxylic acid::US10098902, Example 52::US10603330, Example 52
SMILES: N[C@]1(CN(CCNc2ccc(cc2)-c2ccccc2)C[C@@H]1CCCB(O)O)C(O)=O
InChI Key: InChIKey=GELNOVICZMBBMR-UGKGYDQZSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Arginase-1 (Homo sapiens (Human)) | BDBM290416 ((3R,4S)-3-amino-1-(2-(biphenyl-4-ylamino)ethyl)-4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <250 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Mars, Incorporated US Patent | Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp... | US Patent US10098902 (2018) BindingDB Entry DOI: 10.7270/Q2319XXK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arginase-2, mitochondrial (Homo sapiens (Human)) | BDBM290416 ((3R,4S)-3-amino-1-(2-(biphenyl-4-ylamino)ethyl)-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mars, Incorporated US Patent | Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp... | US Patent US10603330 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arginase-1 (Homo sapiens (Human)) | BDBM290416 ((3R,4S)-3-amino-1-(2-(biphenyl-4-ylamino)ethyl)-4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mars, Incorporated US Patent | Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp... | US Patent US10603330 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arginase-2, mitochondrial (Homo sapiens (Human)) | BDBM290416 ((3R,4S)-3-amino-1-(2-(biphenyl-4-ylamino)ethyl)-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <250 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Mars, Incorporated US Patent | Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp... | US Patent US10098902 (2018) BindingDB Entry DOI: 10.7270/Q2319XXK | |||||||||||
More data for this Ligand-Target Pair |