BDBM293456 US10106527, Compound 60::US10544128, Compound 60::US9951048, Compound 60
SMILES: Cn1cc(nn1)-c1ccc2cnc(NC(=O)c3ccccc3F)cc2c1
InChI Key: InChIKey=LNZOZROJVDQBCF-UHFFFAOYSA-N
Data: 7 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (Homo sapiens (Human)) | BDBM293456![]() (US10106527, Compound 60 | US10544128, Compound 60 ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.70 | n/a | n/a | n/a | 25 |
Samumed, LLC US Patent | Assay Description Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ... | US Patent US10106527 (2018) BindingDB Entry DOI: 10.7270/Q2PN97Q3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM293456![]() (US10106527, Compound 60 | US10544128, Compound 60 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 439 | n/a | n/a | n/a | 25 |
Samumed, LLC US Patent | Assay Description Briefly, recombinant GSK3β kinase, ATP and Ser/Thr peptide 09 are prepared in 1× Kinase buffer to final concentrations of 0.04 μg/mL, 46 ... | US Patent US10106527 (2018) BindingDB Entry DOI: 10.7270/Q2PN97Q3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM293456![]() (US10106527, Compound 60 | US10544128, Compound 60 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 439 | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA | Assay Description The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div... | Bioorg Med Chem Lett 17: 4442-6 (2007) BindingDB Entry DOI: 10.7270/Q2862JRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM293456![]() (US10106527, Compound 60 | US10544128, Compound 60 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 439 | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di... | US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene Wnt-1 (Homo sapiens (human)) | BDBM293456![]() (US10106527, Compound 60 | US10544128, Compound 60 ...) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 680 | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col... | US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (Homo sapiens (Human)) | BDBM293456![]() (US10106527, Compound 60 | US10544128, Compound 60 ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis... | US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (Homo sapiens (Human)) | BDBM293456![]() (US10106527, Compound 60 | US10544128, Compound 60 ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA | Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis... | Bioorg Med Chem Lett 17: 4442-6 (2007) BindingDB Entry DOI: 10.7270/Q2862JRD | |||||||||||
More data for this Ligand-Target Pair |