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Compile Data Set for Download or QSAR

Found 1498 hits Enz. Inhib. hit(s) with Target = 'Proto-oncogene Wnt-1'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384029
PNG
(US10280166, Compound 346)
Show SMILES CC(C)(C)C(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccc(F)s3)c2c1
Show InChI InChI=1S/C27H22FN7OS/c1-27(2,3)26(36)31-16-10-15(12-29-13-16)14-4-5-19-18(11-14)23(35-34-19)25-32-22-17(8-9-30-24(22)33-25)20-6-7-21(28)37-20/h4-13H,1-3H3,(H,31,36)(H,34,35)(H,30,32,33)
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n/an/a 0.400n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384033
PNG
(US10280166, Compound 372)
Show SMILES Cc1ccc(s1)-c1ccnc2[nH]c(nc12)-c1n[nH]c2ccc(cc12)-c1cncc(NC(=O)C(C)(C)C)c1
Show InChI InChI=1S/C28H25N7OS/c1-15-5-8-22(37-15)19-9-10-30-25-23(19)32-26(33-25)24-20-12-16(6-7-21(20)34-35-24)17-11-18(14-29-13-17)31-27(36)28(2,3)4/h5-14H,1-4H3,(H,31,36)(H,34,35)(H,30,32,33)
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n/an/a 0.600n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383959
PNG
(US10280166, Compound 25)
Show SMILES Fc1cccc(c1)-c1ccnc2[nH]c(nc12)-c1n[nH]c2ccc(cc12)-c1cncc(CN2CCC(F)(F)C2)c1
Show InChI InChI=1S/C29H22F3N7/c30-21-3-1-2-19(11-21)22-6-8-34-27-25(22)35-28(36-27)26-23-12-18(4-5-24(23)37-38-26)20-10-17(13-33-14-20)15-39-9-7-29(31,32)16-39/h1-6,8,10-14H,7,9,15-16H2,(H,37,38)(H,34,35,36)
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n/an/a<1n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384010
PNG
(US10280166, Compound 277)
Show SMILES CCCC(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccsc3)c2c1
Show InChI InChI=1S/C26H21N7OS/c1-2-3-22(34)29-18-10-17(12-27-13-18)15-4-5-21-20(11-15)24(33-32-21)26-30-23-19(16-7-9-35-14-16)6-8-28-25(23)31-26/h4-14H,2-3H2,1H3,(H,29,34)(H,32,33)(H,28,30,31)
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n/an/a 1n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383918
PNG
(US10280166, Compound 1)
Show SMILES CCC(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3cccc(F)c3)c2c1
Show InChI InChI=1S/C27H20FN7O/c1-2-23(36)31-19-11-17(13-29-14-19)15-6-7-22-21(12-15)25(35-34-22)27-32-24-20(8-9-30-26(24)33-27)16-4-3-5-18(28)10-16/h3-14H,2H2,1H3,(H,31,36)(H,34,35)(H,30,32,33)
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n/an/a<1n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383939
PNG
(US10280166, Compound 7)
Show SMILES CN(C)c1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3cccc(F)c3)c2c1
Show InChI InChI=1S/C26H20FN7/c1-34(2)19-11-17(13-28-14-19)15-6-7-22-21(12-15)24(33-32-22)26-30-23-20(8-9-29-25(23)31-26)16-4-3-5-18(27)10-16/h3-14H,1-2H3,(H,32,33)(H,29,30,31)
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n/an/a<1n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383956
PNG
(US10280166, Compound 19)
Show SMILES Fc1cccc(c1)-c1ccnc2[nH]c(nc12)-c1n[nH]c2ccc(cc12)-c1cncc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C28H20FN7O/c29-19-3-1-2-17(10-19)21-8-9-31-26-24(21)33-27(34-26)25-22-12-16(6-7-23(22)35-36-25)18-11-20(14-30-13-18)32-28(37)15-4-5-15/h1-3,6-15H,4-5H2,(H,32,37)(H,35,36)(H,31,33,34)
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n/an/a 1n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383965
PNG
(US10280166, Compound 55)
Show SMILES Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccccc3F)c2c1
Show InChI InChI=1S/C24H16FN7/c25-19-4-2-1-3-16(19)17-7-8-28-23-21(17)29-24(30-23)22-18-10-13(5-6-20(18)31-32-22)14-9-15(26)12-27-11-14/h1-12H,26H2,(H,31,32)(H,28,29,30)
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n/an/a 1.80n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383963
PNG
(US10280166, Compound 46)
Show SMILES Fc1ccc(cc1)-c1ccnc2[nH]c(nc12)-c1n[nH]c2ccc(cc12)-c1cncc(NC(=O)C2CCC2)c1
Show InChI InChI=1S/C29H22FN7O/c30-20-7-4-16(5-8-20)22-10-11-32-27-25(22)34-28(35-27)26-23-13-18(6-9-24(23)36-37-26)19-12-21(15-31-14-19)33-29(38)17-2-1-3-17/h4-15,17H,1-3H2,(H,33,38)(H,36,37)(H,32,34,35)
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n/an/a 2n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384020
PNG
(US10280166, Compound 313)
Show SMILES CCC(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3cccs3)c2c1
Show InChI InChI=1S/C25H19N7OS/c1-2-21(33)28-16-10-15(12-26-13-16)14-5-6-19-18(11-14)23(32-31-19)25-29-22-17(20-4-3-9-34-20)7-8-27-24(22)30-25/h3-13H,2H2,1H3,(H,28,33)(H,31,32)(H,27,29,30)
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n/an/a 2n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383937
PNG
(US10280166, Compound 2)
Show SMILES CC(C)CC(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3cccc(F)c3)c2c1
Show InChI InChI=1S/C29H24FN7O/c1-16(2)10-25(38)33-21-12-19(14-31-15-21)17-6-7-24-23(13-17)27(37-36-24)29-34-26-22(8-9-32-28(26)35-29)18-4-3-5-20(30)11-18/h3-9,11-16H,10H2,1-2H3,(H,33,38)(H,36,37)(H,32,34,35)
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University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383991
PNG
(US10280166, Compound 184)
Show SMILES CC(C)CC(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-n3cnc(C)c3)c2c1
Show InChI InChI=1S/C27H25N9O/c1-15(2)8-23(37)31-19-9-18(11-28-12-19)17-4-5-21-20(10-17)24(35-34-21)27-32-25-22(6-7-29-26(25)33-27)36-13-16(3)30-14-36/h4-7,9-15H,8H2,1-3H3,(H,31,37)(H,34,35)(H,29,32,33)
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n/an/a 2.30n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383946
PNG
(US10280166, Compound 9)
Show SMILES CC(C)C(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3cccc(F)c3)c2c1
Show InChI InChI=1S/C28H22FN7O/c1-15(2)28(37)32-20-11-18(13-30-14-20)16-6-7-23-22(12-16)25(36-35-23)27-33-24-21(8-9-31-26(24)34-27)17-4-3-5-19(29)10-17/h3-15H,1-2H3,(H,32,37)(H,35,36)(H,31,33,34)
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n/an/a 3n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM445829
PNG
(US10669240, Compound 1141)
Show SMILES CC1CN(CC(C)O1)c1ccc(NC(=O)c2n[nH]c3ccc(cc23)-c2cncc(CN3CCCCC3)c2)cn1
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Samumed, LLC

US Patent


Assay Description
Reporter cell lines were generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a W...

US Patent US10669240 (2020)


BindingDB Entry DOI: 10.7270/Q2HQ42ZD
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384039
PNG
(US10280166, Compound 433)
Show SMILES CCCC(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3cc(F)cc(CNS(C)(=O)=O)c3)c2c1
Show InChI InChI=1S/C30H27FN8O3S/c1-3-4-26(40)35-22-12-20(15-32-16-22)18-5-6-25-24(13-18)28(39-38-25)30-36-27-23(7-8-33-29(27)37-30)19-9-17(10-21(31)11-19)14-34-43(2,41)42/h5-13,15-16,34H,3-4,14H2,1-2H3,(H,35,40)(H,38,39)(H,33,36,37)
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University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383972
PNG
(US10280166, Compound 82)
Show SMILES c1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3cccnc3)c2c1
Show InChI InChI=1S/C23H15N7/c1-3-15(12-24-8-1)14-5-6-19-18(11-14)21(30-29-19)23-27-20-17(7-10-26-22(20)28-23)16-4-2-9-25-13-16/h1-13H,(H,29,30)(H,26,27,28)
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n/an/a 3.5n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM346341
PNG
(US10202377, Compound 367)
Show SMILES Cc1ccc(s1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1cncc(N)c1
Show InChI InChI=1S/C23H17N7S/c1-12-5-6-20(31-12)15-3-2-4-17-21(15)28-23(27-17)22-16-8-18(26-11-19(16)29-30-22)13-7-14(24)10-25-9-13/h2-11H,24H2,1H3,(H,27,28)(H,29,30)
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Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...

US Patent US10202377 (2019)


BindingDB Entry DOI: 10.7270/Q2639RV7
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383960
PNG
(US10280166, Compound 28)
Show SMILES CC(C)CC(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccc(F)cc3)c2c1
Show InChI InChI=1S/C29H24FN7O/c1-16(2)11-25(38)33-21-12-19(14-31-15-21)18-5-8-24-23(13-18)27(37-36-24)29-34-26-22(9-10-32-28(26)35-29)17-3-6-20(30)7-4-17/h3-10,12-16H,11H2,1-2H3,(H,33,38)(H,36,37)(H,32,34,35)
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University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM445759
PNG
(US10669240, Compound 55)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2n[nH]c3ccc(cc23)-c2cncc(CN3CCC(F)(F)C3)c2)cn1
Show InChI InChI=1S/C28H30F2N8O/c1-36-8-10-38(11-9-36)25-5-3-22(16-32-25)33-27(39)26-23-13-20(2-4-24(23)34-35-26)21-12-19(14-31-15-21)17-37-7-6-28(29,30)18-37/h2-5,12-16H,6-11,17-18H2,1H3,(H,33,39)(H,34,35)
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Samumed, LLC

US Patent


Assay Description
Reporter cell lines were generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a W...

US Patent US10669240 (2020)


BindingDB Entry DOI: 10.7270/Q2HQ42ZD
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM346315
PNG
(US10202377, Compound 269)
Show SMILES CC(C)C(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccsc1
Show InChI InChI=1S/C26H21N7OS/c1-14(2)26(34)29-17-8-16(10-27-11-17)21-9-19-22(12-28-21)32-33-24(19)25-30-20-5-3-4-18(23(20)31-25)15-6-7-35-13-15/h3-14H,1-2H3,(H,29,34)(H,30,31)(H,32,33)
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Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...

US Patent US10202377 (2019)


BindingDB Entry DOI: 10.7270/Q2639RV7
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384032
PNG
(US10280166, Compound 367)
Show SMILES Cc1ccc(s1)-c1ccnc2[nH]c(nc12)-c1n[nH]c2ccc(cc12)-c1cncc(N)c1
Show InChI InChI=1S/C23H17N7S/c1-12-2-5-19(31-12)16-6-7-26-22-20(16)27-23(28-22)21-17-9-13(3-4-18(17)29-30-21)14-8-15(24)11-25-10-14/h2-11H,24H2,1H3,(H,29,30)(H,26,27,28)
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n/an/a 4.30n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM346283
PNG
(US10202377, Compound 82)
Show SMILES c1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cccnc1
Show InChI InChI=1S/C23H15N7/c1-6-16(14-4-2-8-24-11-14)21-18(7-1)27-23(28-21)22-17-10-19(15-5-3-9-25-12-15)26-13-20(17)29-30-22/h1-13H,(H,27,28)(H,29,30)
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n/an/a 4.5n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...

US Patent US10202377 (2019)


BindingDB Entry DOI: 10.7270/Q2639RV7
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383993
PNG
(US10280166, Compound 202)
Show SMILES Cc1cn(cn1)-c1ccnc2[nH]c(nc12)-c1n[nH]c2ccc(cc12)-c1cncc(NC(=O)C2CCC2)c1
Show InChI InChI=1S/C27H23N9O/c1-15-13-36(14-30-15)22-7-8-29-25-24(22)32-26(33-25)23-20-10-17(5-6-21(20)34-35-23)18-9-19(12-28-11-18)31-27(37)16-3-2-4-16/h5-14,16H,2-4H2,1H3,(H,31,37)(H,34,35)(H,29,32,33)
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n/an/a 4.70n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384028
PNG
(US10280166, Compound 340)
Show SMILES CC(C)CC(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccc(F)s3)c2c1
Show InChI InChI=1S/C27H22FN7OS/c1-14(2)9-23(36)31-17-10-16(12-29-13-17)15-3-4-20-19(11-15)25(35-34-20)27-32-24-18(7-8-30-26(24)33-27)21-5-6-22(28)37-21/h3-8,10-14H,9H2,1-2H3,(H,31,36)(H,34,35)(H,30,32,33)
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n/an/a 4.90n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384016
PNG
(US10280166, Compound 298)
Show SMILES CC(C)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccoc3)c2c1
Show InChI InChI=1S/C25H21N7O/c1-14(2)28-18-9-17(11-26-12-18)15-3-4-21-20(10-15)23(32-31-21)25-29-22-19(16-6-8-33-13-16)5-7-27-24(22)30-25/h3-14,28H,1-2H3,(H,31,32)(H,27,29,30)
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n/an/a 5n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM445758
PNG
(US10669240, Compound 54)
Show SMILES COc1ccc(NC(=O)c2n[nH]c3ccc(cc23)-c2cncc(CN3CCC(F)(F)C3)c2)cn1
Show InChI InChI=1S/C24H22F2N6O2/c1-34-21-5-3-18(12-28-21)29-23(33)22-19-9-16(2-4-20(19)30-31-22)17-8-15(10-27-11-17)13-32-7-6-24(25,26)14-32/h2-5,8-12H,6-7,13-14H2,1H3,(H,29,33)(H,30,31)
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n/an/a 5n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Reporter cell lines were generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a W...

US Patent US10669240 (2020)


BindingDB Entry DOI: 10.7270/Q2HQ42ZD
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384057
PNG
(US10280166, Compound 1875)
Show SMILES Fc1cccc(c1)-c1ccnc2[nH]c(nc12)-c1n[nH]c2ccc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C22H14FN7/c23-15-3-1-2-13(8-15)16-6-7-24-21-19(16)27-22(28-21)20-17-9-12(14-10-25-26-11-14)4-5-18(17)29-30-20/h1-11H,(H,25,26)(H,29,30)(H,24,27,28)
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n/an/a 5n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384007
PNG
(US10280166, Compound 269)
Show SMILES CC(C)C(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccsc3)c2c1
Show InChI InChI=1S/C26H21N7OS/c1-14(2)26(34)29-18-9-17(11-27-12-18)15-3-4-21-20(10-15)23(33-32-21)25-30-22-19(16-6-8-35-13-16)5-7-28-24(22)31-25/h3-14H,1-2H3,(H,29,34)(H,32,33)(H,28,30,31)
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n/an/a 5.10n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384015
PNG
(US10280166, Compound 295)
Show SMILES CC(C)C(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccoc3)c2c1
Show InChI InChI=1S/C26H21N7O2/c1-14(2)26(34)29-18-9-17(11-27-12-18)15-3-4-21-20(10-15)23(33-32-21)25-30-22-19(16-6-8-35-13-16)5-7-28-24(22)31-25/h3-14H,1-2H3,(H,29,34)(H,32,33)(H,28,30,31)
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n/an/a 5.10n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384011
PNG
(US10280166, Compound 279)
Show SMILES O=C(Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccsc3)c2c1)C1CC1
Show InChI InChI=1S/C26H19N7OS/c34-26(14-1-2-14)29-18-9-17(11-27-12-18)15-3-4-21-20(10-15)23(33-32-21)25-30-22-19(16-6-8-35-13-16)5-7-28-24(22)31-25/h3-14H,1-2H2,(H,29,34)(H,32,33)(H,28,30,31)
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n/an/a 5.20n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383971
PNG
(US10280166, Compound 81)
Show SMILES Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3cccnc3)c2c1
Show InChI InChI=1S/C23H16N8/c24-16-8-15(11-26-12-16)13-3-4-19-18(9-13)21(31-30-19)23-28-20-17(5-7-27-22(20)29-23)14-2-1-6-25-10-14/h1-12H,24H2,(H,30,31)(H,27,28,29)
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n/an/a 5.80n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384041
PNG
(US10280166, Compound 442)
Show SMILES CS(=O)(=O)NCc1cc(F)cc(c1)-c1ccnc2[nH]c(nc12)-c1n[nH]c2ccc(cc12)-c1cncnc1
Show InChI InChI=1S/C25H19FN8O2S/c1-37(35,36)30-10-14-6-16(8-18(26)7-14)19-4-5-29-24-22(19)31-25(32-24)23-20-9-15(2-3-21(20)33-34-23)17-11-27-13-28-12-17/h2-9,11-13,30H,10H2,1H3,(H,33,34)(H,29,31,32)
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n/an/a 5.80n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383967
PNG
(US10280166, Compound 61)
Show SMILES CC(C)C(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccccc3F)c2c1
Show InChI InChI=1S/C28H22FN7O/c1-15(2)28(37)32-18-11-17(13-30-14-18)16-7-8-23-21(12-16)25(36-35-23)27-33-24-20(9-10-31-26(24)34-27)19-5-3-4-6-22(19)29/h3-15H,1-2H3,(H,32,37)(H,35,36)(H,31,33,34)
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n/an/a 6n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384017
PNG
(US10280166, Compound 304)
Show SMILES CCCCC(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccoc3)c2c1
Show InChI InChI=1S/C27H23N7O2/c1-2-3-4-23(35)30-19-11-18(13-28-14-19)16-5-6-22-21(12-16)25(34-33-22)27-31-24-20(17-8-10-36-15-17)7-9-29-26(24)32-27/h5-15H,2-4H2,1H3,(H,30,35)(H,33,34)(H,29,31,32)
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n/an/a 6n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384037
PNG
(US10280166, Compound 421)
Show SMILES Cc1ccncc1-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3cc(F)cc(CNS(C)(=O)=O)c3)c2c1
Show InChI InChI=1S/C27H22FN7O2S/c1-15-5-7-29-14-22(15)17-3-4-23-21(12-17)25(35-34-23)27-32-24-20(6-8-30-26(24)33-27)18-9-16(10-19(28)11-18)13-31-38(2,36)37/h3-12,14,31H,13H2,1-2H3,(H,34,35)(H,30,32,33)
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n/an/a 6.10n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM346318
PNG
(US10202377, Compound 280)
Show SMILES O=C(Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccsc1)C1CCC1
Show InChI InChI=1S/C27H21N7OS/c35-27(15-3-1-4-15)30-18-9-17(11-28-12-18)22-10-20-23(13-29-22)33-34-25(20)26-31-21-6-2-5-19(24(21)32-26)16-7-8-36-14-16/h2,5-15H,1,3-4H2,(H,30,35)(H,31,32)(H,33,34)
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n/an/a 6.20n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...

US Patent US10202377 (2019)


BindingDB Entry DOI: 10.7270/Q2639RV7
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384026
PNG
(US10280166, Compound 333)
Show SMILES O=C(Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3cccs3)c2c1)C1CCCC1
Show InChI InChI=1S/C28H23N7OS/c36-28(16-4-1-2-5-16)31-19-12-18(14-29-15-19)17-7-8-22-21(13-17)25(35-34-22)27-32-24-20(23-6-3-11-37-23)9-10-30-26(24)33-27/h3,6-16H,1-2,4-5H2,(H,31,36)(H,34,35)(H,30,32,33)
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n/an/a 6.30n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384034
PNG
(US10280166, Compound 373)
Show SMILES CC(C)C(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccc(C)s3)c2c1
Show InChI InChI=1S/C27H23N7OS/c1-14(2)27(35)30-18-10-17(12-28-13-18)16-5-6-21-20(11-16)24(34-33-21)26-31-23-19(8-9-29-25(23)32-26)22-7-4-15(3)36-22/h4-14H,1-3H3,(H,30,35)(H,33,34)(H,29,31,32)
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n/an/a 6.40n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384006
PNG
(US10280166, Compound 268)
Show SMILES CC(C)(C)C(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccsc3)c2c1
Show InChI InChI=1S/C27H23N7OS/c1-27(2,3)26(35)30-18-10-17(12-28-13-18)15-4-5-21-20(11-15)23(34-33-21)25-31-22-19(16-7-9-36-14-16)6-8-29-24(22)32-25/h4-14H,1-3H3,(H,30,35)(H,33,34)(H,29,31,32)
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n/an/a 6.5n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384018
PNG
(US10280166, Compound 306)
Show SMILES O=C(Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccoc3)c2c1)C1CCC1
Show InChI InChI=1S/C27H21N7O2/c35-27(15-2-1-3-15)30-19-10-18(12-28-13-19)16-4-5-22-21(11-16)24(34-33-22)26-31-23-20(17-7-9-36-14-17)6-8-29-25(23)32-26/h4-15H,1-3H2,(H,30,35)(H,33,34)(H,29,31,32)
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n/an/a 6.70n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383973
PNG
(US10280166, Compound 87)
Show SMILES CC(C)C(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3cccnc3)c2c1
Show InChI InChI=1S/C27H22N8O/c1-15(2)27(36)31-19-10-18(13-29-14-19)16-5-6-22-21(11-16)24(35-34-22)26-32-23-20(7-9-30-25(23)33-26)17-4-3-8-28-12-17/h3-15H,1-2H3,(H,31,36)(H,34,35)(H,30,32,33)
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n/an/a 6.80n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM346320
PNG
(US10202377, Compound 288)
Show SMILES CC(C)CC(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1ccoc1
Show InChI InChI=1S/C27H23N7O2/c1-15(2)8-24(35)30-18-9-17(11-28-12-18)22-10-20-23(13-29-22)33-34-26(20)27-31-21-5-3-4-19(25(21)32-27)16-6-7-36-14-16/h3-7,9-15H,8H2,1-2H3,(H,30,35)(H,31,32)(H,33,34)
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US Patent
n/an/a 6.80n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...

US Patent US10202377 (2019)


BindingDB Entry DOI: 10.7270/Q2639RV7
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384031
PNG
(US10280166, Compound 358)
Show SMILES Fc1ccc(s1)-c1ccnc2[nH]c(nc12)-c1n[nH]c2ccc(cc12)-c1cncc(NC(=O)C2CCC2)c1
Show InChI InChI=1S/C27H20FN7OS/c28-22-7-6-21(37-22)18-8-9-30-25-23(18)32-26(33-25)24-19-11-15(4-5-20(19)34-35-24)16-10-17(13-29-12-16)31-27(36)14-2-1-3-14/h4-14H,1-3H2,(H,31,36)(H,34,35)(H,30,32,33)
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n/an/a 6.90n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM445786
PNG
(US10669240, Compound 82)
Show SMILES CC1CCN(Cc2cncc(c2)-c2ccc3[nH]nc(C(=O)Nc4cccnc4)c3c2)CC1
Show InChI InChI=1S/C25H26N6O/c1-17-6-9-31(10-7-17)16-18-11-20(14-27-13-18)19-4-5-23-22(12-19)24(30-29-23)25(32)28-21-3-2-8-26-15-21/h2-5,8,11-15,17H,6-7,9-10,16H2,1H3,(H,28,32)(H,29,30)
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n/an/a 7n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Reporter cell lines were generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a W...

US Patent US10669240 (2020)


BindingDB Entry DOI: 10.7270/Q2HQ42ZD
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383992
PNG
(US10280166, Compound 190)
Show SMILES Cc1cn(cn1)-c1ccnc2[nH]c(nc12)-c1n[nH]c2ccc(cc12)-c1cncc(NC(=O)C(C)(C)C)c1
Show InChI InChI=1S/C27H25N9O/c1-15-13-36(14-30-15)21-7-8-29-24-23(21)32-25(33-24)22-19-10-16(5-6-20(19)34-35-22)17-9-18(12-28-11-17)31-26(37)27(2,3)4/h5-14H,1-4H3,(H,31,37)(H,34,35)(H,29,32,33)
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n/an/a 7.40n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM346309
PNG
(US10202377, Compound 238)
Show SMILES c1ccc2[nH]c(nc2c1)-c1n[nH]c2cnc(cc12)-c1cccnc1
Show InChI InChI=1S/C18H12N6/c1-2-6-14-13(5-1)21-18(22-14)17-12-8-15(11-4-3-7-19-9-11)20-10-16(12)23-24-17/h1-10H,(H,21,22)(H,23,24)
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n/an/a 7.70n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...

US Patent US10202377 (2019)


BindingDB Entry DOI: 10.7270/Q2639RV7
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM383983
PNG
(US10280166, Compound 148)
Show SMILES CCCCC(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccccn3)c2c1
Show InChI InChI=1S/C28H24N8O/c1-2-3-7-24(37)32-19-13-18(15-29-16-19)17-8-9-23-21(14-17)26(36-35-23)28-33-25-20(10-12-31-27(25)34-28)22-6-4-5-11-30-22/h4-6,8-16H,2-3,7H2,1H3,(H,32,37)(H,35,36)(H,31,33,34)
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n/an/a 8.10n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384009
PNG
(US10280166, Compound 271)
Show SMILES O=C(Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3ccsc3)c2c1)c1ccccc1
Show InChI InChI=1S/C29H19N7OS/c37-29(17-4-2-1-3-5-17)32-21-12-20(14-30-15-21)18-6-7-24-23(13-18)26(36-35-24)28-33-25-22(19-9-11-38-16-19)8-10-31-27(25)34-28/h1-16H,(H,32,37)(H,35,36)(H,31,33,34)
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n/an/a 8.40n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM384022
PNG
(US10280166, Compound 320)
Show SMILES CC(C)(C)C(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4c(ccnc4[nH]3)-c3cccs3)c2c1
Show InChI InChI=1S/C27H23N7OS/c1-27(2,3)26(35)30-17-11-16(13-28-14-17)15-6-7-20-19(12-15)23(34-33-20)25-31-22-18(21-5-4-10-36-21)8-9-29-24(22)32-25/h4-14H,1-3H3,(H,30,35)(H,33,34)(H,29,31,32)
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n/an/a 8.80n/an/an/an/an/an/a



University of Nottingham



Assay Description
Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., colon cancer) or primary cells (e.g., IEC-6 intestinal cells) wit...

Br J Pharmacol 144: 317-22 (2005)


BindingDB Entry DOI: 10.7270/Q22Z17VC
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM445831
PNG
(US10669240, Compound 1153)
Show SMILES Fc1cc2[nH]nc(C(=O)Nc3cccnc3)c2cc1-c1cncc(CN2CCCCC2)c1
Show InChI InChI=1S/C24H23FN6O/c25-21-11-22-20(23(30-29-22)24(32)28-18-5-4-6-26-14-18)10-19(21)17-9-16(12-27-13-17)15-31-7-2-1-3-8-31/h4-6,9-14H,1-3,7-8,15H2,(H,28,32)(H,29,30)
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n/an/a 9n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Reporter cell lines were generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a W...

US Patent US10669240 (2020)


BindingDB Entry DOI: 10.7270/Q2HQ42ZD
More data for this
Ligand-Target Pair
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