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SMILES: CC1CCN(Cc2cncc(c2)-c2ccc3[nH]nc(C(=O)Nc4cccnc4)c3c2)CC1

InChI Key: InChIKey=OLUJPDZZXTUOGS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 445786   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene Wnt-1 (Homo sapiens (human))	BDBM445786 (US10669240, Compound 82) Show SMILES CC1CCN(Cc2cncc(c2)-c2ccc3[nH]nc(C(=O)Nc4cccnc4)c3c2)CC1 Show InChI InChI=1S/C25H26N6O/c1-17-6-9-31(10-7-17)16-18-11-20(14-27-13-18)19-4-5-23-22(12-19)24(30-29-23)25(32)28-21-3-2-8-26-15-21/h2-5,8,11-15,17H,6-7,9-10,16H2,1H3,(H,28,32)(H,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description Reporter cell lines were generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a W...				US Patent US10669240 (2020)
					More data for this Ligand-Target Pair
Pulmonary surfactant-associated protein A1 (Human)	BDBM445786 (US10669240, Compound 82) Show SMILES CC1CCN(Cc2cncc(c2)-c2ccc3[nH]nc(C(=O)Nc4cccnc4)c3c2)CC1 Show InChI InChI=1S/C25H26N6O/c1-17-6-9-31(10-7-17)16-18-11-20(14-27-13-18)19-4-5-23-22(12-19)24(30-29-23)25(32)28-21-3-2-8-26-15-21/h2-5,8,11-15,17H,6-7,9-10,16H2,1H3,(H,28,32)(H,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	129	n/a	n/a	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 8-point dose-response curves f...				US Patent US10669240 (2020)
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM445786 (US10669240, Compound 82) Show SMILES CC1CCN(Cc2cncc(c2)-c2ccc3[nH]nc(C(=O)Nc4cccnc4)c3c2)CC1 Show InChI InChI=1S/C25H26N6O/c1-17-6-9-31(10-7-17)16-18-11-20(14-27-13-18)19-4-5-23-22(12-19)24(30-29-23)25(32)28-21-3-2-8-26-15-21/h2-5,8,11-15,17H,6-7,9-10,16H2,1H3,(H,28,32)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description SH-SY5Y cells are cultured in DMEM/F-12 medium supplemented with 15% FBS, Non-essential Amino Acid and Penicillin/Streptamycin. Two days before treat...				US Patent US10669240 (2020)
					More data for this Ligand-Target Pair