BDBM301795 N-[6-(2-Benzyloxy-ethoxy)-1H-indazol-3-yl]-4-methyl-(1-methylpiperidin-4-yl)-amino-benzamide ::US9597317, 23
SMILES: CN1CCC(CC1)c1c(C)ccc(C(=O)Nc2n[nH]c3cc(OCCOCc4ccccc4)ccc23)c1N
InChI Key: InChIKey=ZALJVUSMGDIXNX-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM301795![]() (N-[6-(2-Benzyloxy-ethoxy)-1H-indazol-3-yl]-4-methy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 109 | n/a | n/a | n/a | n/a | n/a | n/a |
NERVIANO MEDICAL SCIENCES S.R.L. US Patent | Assay Description i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ... | US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human)) | BDBM301795![]() (N-[6-(2-Benzyloxy-ethoxy)-1H-indazol-3-yl]-4-methy...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
NERVIANO MEDICAL SCIENCES S.R.L. US Patent | Assay Description i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p... | US Patent US9597317 (2017) BindingDB Entry DOI: 10.7270/Q2N58PDX | |||||||||||
More data for this Ligand-Target Pair |