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SMILES: Cc1ccc2c(nn(Cc3cccc(F)c3F)c2n1)-c1nnc2c(NC(=O)C22CC2)n1

InChI Key: InChIKey=GZLMBGOBOATBRU-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 312963   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM312963
PNG
(3′-[1-(2,3-Difluorobenzyl)-6-methyl-1H-pyraz...)
Show SMILES Cc1ccc2c(nn(Cc3cccc(F)c3F)c2n1)-c1nnc2c(NC(=O)C22CC2)n1
Show InChI InChI=1S/C21H15F2N7O/c1-10-5-6-12-15(17-25-18-16(27-28-17)21(7-8-21)20(31)26-18)29-30(19(12)24-10)9-11-3-2-4-13(22)14(11)23/h2-6H,7-9H2,1H3,(H,25,26,28,31)
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US Patent
n/an/a 21n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...

US Patent US9605008 (2017)


BindingDB Entry DOI: 10.7270/Q2DZ0BC2
More data for this
Ligand-Target Pair