BDBM337049 US9745291, Compound 95::US9765068, Compound 95

SMILES: OC(CNC(=O)COc1ccc2n(ncc2c1)C1CCNC1)CN1CCc2ccccc2C1

InChI Key: InChIKey=TXYOLEJQJXMWPZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337049   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM337049 (US9745291, Compound 95 | US9765068, Compound 95) Show SMILES OC(CNC(=O)COc1ccc2n(ncc2c1)C1CCNC1)CN1CCc2ccccc2C1 Show InChI InChI=1S/C25H31N5O3/c31-22(16-29-10-8-18-3-1-2-4-19(18)15-29)14-27-25(32)17-33-23-5-6-24-20(11-23)12-28-30(24)21-7-9-26-13-21/h1-6,11-12,21-22,26,31H,7-10,13-17H2,(H,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Molecular Biology: Full-length human PRMT5 (NM_006109.3) transcript variant 1 clone was amplified from a fetal brain cDNA library, incorporating flan...				US Patent US9765068 (2017) BindingDB Entry DOI: 10.7270/Q2959KN3
					More data for this Ligand-Target Pair
PRMT5/MEP50 Enzyme (Homo sapiens (Human))	BDBM337049 (US9745291, Compound 95 | US9765068, Compound 95) Show SMILES OC(CNC(=O)COc1ccc2n(ncc2c1)C1CCNC1)CN1CCc2ccccc2C1 Show InChI InChI=1S/C25H31N5O3/c31-22(16-29-10-8-18-3-1-2-4-19(18)15-29)14-27-25(32)17-33-23-5-6-24-20(11-23)12-28-30(24)21-7-9-26-13-21/h1-6,11-12,21-22,26,31H,7-10,13-17H2,(H,27,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US9745291 (2017) BindingDB Entry DOI: 10.7270/Q2J1058K
					More data for this Ligand-Target Pair