BDBM345281 2-[[1-[(2-Chlorophenyl)methyl]-5-(3- isobutoxyphenyl)pyrazol-3-yl]methoxy]-2- methyl-propanoic acid. 1HNMR (CDCl3): $#948; 0.95 (s, 3H)(, 0.96 (s, 3H), 1.56 (s, 6H), 1.97-2.03 (m, 1H), 3.49 (d, 2H), 4.63 (s, 2H), 5.43 (s, 2H), 6.41 (s, 1H), 6.73-6.80 (m, 2H), 6.84- 6.92 (m, 2H), 7.19-7.28 (m, 3H), 7.33- 7.35 (m, 1H).::US10202350, Example 27::US10214492, Example 27
SMILES: CC(C)COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
InChI Key: InChIKey=RUFWXTRLNGUAJT-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Monocarboxylate transporter 4 (Homo sapiens (Human)) | BDBM345281![]() (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- isobutoxyphe...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC US Patent | Assay Description MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ... | US Patent US10202350 (2019) BindingDB Entry DOI: 10.7270/Q20K2BPB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Malignant T-cell-amplified sequence 1 (Homo sapiens (human)) | BDBM345281![]() (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- isobutoxyphe...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 302 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC US Patent | Assay Description MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those... | US Patent US10202350 (2019) BindingDB Entry DOI: 10.7270/Q20K2BPB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 1 (Homo sapiens (Human)) | BDBM345281![]() (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- isobutoxyphe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 1 (Homo sapiens (Human)) | BDBM345281![]() (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- isobutoxyphe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 302 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC US Patent | Assay Description MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those... | US Patent US10214492 (2019) BindingDB Entry DOI: 10.7270/Q2Q81GC0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 4 (Homo sapiens (Human)) | BDBM345281![]() (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- isobutoxyphe...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 4 (Homo sapiens (Human)) | BDBM345281![]() (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- isobutoxyphe...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC US Patent | Assay Description MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ... | US Patent US10214492 (2019) BindingDB Entry DOI: 10.7270/Q2Q81GC0 | |||||||||||
More data for this Ligand-Target Pair |