BDBM347640 4-Methyl-2-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)ethynyl)pyridine::US9790203, Example 8

SMILES: Cc1ccnc(c1)C#Cc1ccc(cc1)-c1nn(C)cc1-c1ccncc1

InChI Key: InChIKey=UJQHSUJSPBBMNP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 347640   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM347640 (4-Methyl-2-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyraz...) Show SMILES Cc1ccnc(c1)C#Cc1ccc(cc1)-c1nn(C)cc1-c1ccncc1 Show InChI InChI=1S/C23H18N4/c1-17-9-14-25-21(15-17)8-5-18-3-6-20(7-4-18)23-22(16-27(2)26-23)19-10-12-24-13-11-19/h3-4,6-7,9-16H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG US Patent					Assay Description The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...				US Patent US9790203 (2017) BindingDB Entry DOI: 10.7270/Q2ZG6VD4
					More data for this Ligand-Target Pair