BDBM350005 1-((4-(5-amino-6-(1- (3,5- dimethoxyphenyl)-6- oxo-1,6- dihydropyridazin-3- yl)pyrazin-2-yl)-1H- pyrazol-1- yl)methyl)cyclopropane- 1-carbonitrile::US10208024, Example 4::US10766881, Example 4

SMILES: COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2(CC2)C#N)c1

InChI Key: InChIKey=BTGLYCHFNHKNDV-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 350005   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM350005 (1-((4-(5-amino-6-(1- (3,5- dimethoxyphenyl)-6- oxo...) Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2(CC2)C#N)c1 Show InChI InChI=1S/C24H22N8O3/c1-34-17-7-16(8-18(9-17)35-2)32-21(33)4-3-19(30-32)22-23(26)27-11-20(29-22)15-10-28-31(12-15)14-24(13-25)5-6-24/h3-4,7-12H,5-6,14H2,1-2H3,(H2,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.4	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM350005 (1-((4-(5-amino-6-(1- (3,5- dimethoxyphenyl)-6- oxo...) Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2(CC2)C#N)c1 Show InChI InChI=1S/C24H22N8O3/c1-34-17-7-16(8-18(9-17)35-2)32-21(33)4-3-19(30-32)22-23(26)27-11-20(29-22)15-10-28-31(12-15)14-24(13-25)5-6-24/h3-4,7-12H,5-6,14H2,1-2H3,(H2,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3) (R397-T806) (Homo sapiens (Human))	BDBM350005 (1-((4-(5-amino-6-(1- (3,5- dimethoxyphenyl)-6- oxo...) Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2(CC2)C#N)c1 Show InChI InChI=1S/C24H22N8O3/c1-34-17-7-16(8-18(9-17)35-2)32-21(33)4-3-19(30-32)22-23(26)27-11-20(29-22)15-10-28-31(12-15)14-24(13-25)5-6-24/h3-4,7-12H,5-6,14H2,1-2H3,(H2,26,27)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent									US Patent US10766881 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731) (Homo sapiens (Human))	BDBM350005 (1-((4-(5-amino-6-(1- (3,5- dimethoxyphenyl)-6- oxo...) Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2(CC2)C#N)c1 Show InChI InChI=1S/C24H22N8O3/c1-34-17-7-16(8-18(9-17)35-2)32-21(33)4-3-19(30-32)22-23(26)27-11-20(29-22)15-10-28-31(12-15)14-24(13-25)5-6-24/h3-4,7-12H,5-6,14H2,1-2H3,(H2,26,27)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.4	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description To measure FGFR1 kinase activity, 200 pM His-tagged recombinant human FGFR1 catalytic domain (amino acids 308-731) (Life Technologies Cat. No. PR4660...				US Patent US10766881 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822) (Homo sapiens (Human))	BDBM350005 (1-((4-(5-amino-6-(1- (3,5- dimethoxyphenyl)-6- oxo...) Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2(CC2)C#N)c1 Show InChI InChI=1S/C24H22N8O3/c1-34-17-7-16(8-18(9-17)35-2)32-21(33)4-3-19(30-32)22-23(26)27-11-20(29-22)15-10-28-31(12-15)14-24(13-25)5-6-24/h3-4,7-12H,5-6,14H2,1-2H3,(H2,26,27)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent									US Patent US10766881 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM350005 (1-((4-(5-amino-6-(1- (3,5- dimethoxyphenyl)-6- oxo...) Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2(CC2)C#N)c1 Show InChI InChI=1S/C24H22N8O3/c1-34-17-7-16(8-18(9-17)35-2)32-21(33)4-3-19(30-32)22-23(26)27-11-20(29-22)15-10-28-31(12-15)14-24(13-25)5-6-24/h3-4,7-12H,5-6,14H2,1-2H3,(H2,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair