| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 1 [308-731] |
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| Ligand | BDBM350005 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LanthaScreen Assay |
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| IC50 | 15.4±n/a nM |
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| Citation |  Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent US10766881 Publication Date 9/8/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 1 [308-731] |
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| Name: | Fibroblast growth factor receptor 1 [308-731] |
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| Synonyms: | BFGFR | CEK | FGFBR | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731) | HBGFR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 47326.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 308-731 |
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| Residue: | 424 |
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| Sequence: | VQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPA
VMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQV
TVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEG
CFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINL
LGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQV
ARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWM
APEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTN
ELYM
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| BDBM350005 |
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| n/a |
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| Name | BDBM350005 |
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| Synonyms: | 1-((4-(5-amino-6-(1- (3,5- dimethoxyphenyl)-6- oxo-1,6- dihydropyridazin-3- yl)pyrazin-2-yl)-1H- pyrazol-1- yl)methyl)cyclopropane- 1-carbonitrile | US10208024, Example 4 | US10766881, Example 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22N8O3 |
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| Mol. Mass. | 470.4833 |
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| SMILES | COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC2(CC2)C#N)c1 |
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| Structure | 
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