BDBM35426 5-({4-[2-cyano-2-(4-fluorophenyl)vinyl]-2-ethoxyphenoxy}methyl)-2-furoic acid::5-[[4-[(E)-2-cyano-2-(4-fluorophenyl)ethenyl]-2-ethoxy-phenoxy]methyl]furan-2-carboxylic acid::5-[[4-[(E)-2-cyano-2-(4-fluorophenyl)ethenyl]-2-ethoxyphenoxy]methyl]-2-furancarboxylic acid::5-[[4-[(E)-2-cyano-2-(4-fluorophenyl)ethenyl]-2-ethoxyphenoxy]methyl]furan-2-carboxylic acid::5-[[4-[(E)-2-cyano-2-(4-fluorophenyl)vinyl]-2-ethoxy-phenoxy]methyl]-2-furoic acid::MLS000051448::SMR000079789::cid_2224422

SMILES: CCOc1cc(\C=C(\C#N)c2ccc(F)cc2)ccc1OCc1ccc(o1)C(O)=O

InChI Key: InChIKey=BNQCUGJTLBFRPS-BOPFTXTBSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 35426   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual Specificity Protein Phosphatase 1 (Homo sapiens (Human))	BDBM35426 (5-({4-[2-cyano-2-(4-fluorophenyl)vinyl]-2-ethoxyph...) Show SMILES CCOc1cc(\C=C(\C#N)c2ccc(F)cc2)ccc1OCc1ccc(o1)C(O)=O Show InChI InChI=1S/C23H18FNO5/c1-2-28-22-12-15(11-17(13-25)16-4-6-18(24)7-5-16)3-9-20(22)29-14-19-8-10-21(30-19)23(26)27/h3-12H,2,14H2,1H3,(H,26,27)/b17-11-	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	3.61E+4	n/a	n/a	n/a	n/a	7.0	22
University of Pittsburgh Molecular Library Screening Center Curated by PubChem BioAssay					Assay Description The MKP-1 HTS confirmation dose response assay has been developed to confirm actives identified in the MH-76391 In vitro HTS assay for MKP-1 inhibito...				PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2F769WQ
					More data for this Ligand-Target Pair
Dual Specificity Protein Phosphatase 1 (Homo sapiens (Human))	BDBM35426 (5-({4-[2-cyano-2-(4-fluorophenyl)vinyl]-2-ethoxyph...) Show SMILES CCOc1cc(\C=C(\C#N)c2ccc(F)cc2)ccc1OCc1ccc(o1)C(O)=O Show InChI InChI=1S/C23H18FNO5/c1-2-28-22-12-15(11-17(13-25)16-4-6-18(24)7-5-16)3-9-20(22)29-14-19-8-10-21(30-19)23(26)27/h3-12H,2,14H2,1H3,(H,26,27)/b17-11-	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	4.18E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Molecular Library Screening Center Curated by PubChem BioAssay					Assay Description The MKP-1 dose response Active/Probe assessment-DTT assay has been developed to evaluate the effects of increased DTT concentration on the MKP-1 inhi...				PubChem Bioassay (2006) BindingDB Entry DOI: 10.7270/Q20863PV
					More data for this Ligand-Target Pair
Dual Specificity Protein Phosphatase 1 (Homo sapiens (Human))	BDBM35426 (5-({4-[2-cyano-2-(4-fluorophenyl)vinyl]-2-ethoxyph...) Show SMILES CCOc1cc(\C=C(\C#N)c2ccc(F)cc2)ccc1OCc1ccc(o1)C(O)=O Show InChI InChI=1S/C23H18FNO5/c1-2-28-22-12-15(11-17(13-25)16-4-6-18(24)7-5-16)3-9-20(22)29-14-19-8-10-21(30-19)23(26)27/h3-12H,2,14H2,1H3,(H,26,27)/b17-11-	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	4.18E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Molecular Library Screening Center Curated by PubChem BioAssay					Assay Description The MKP-1 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-1...				PubChem Bioassay (2006) BindingDB Entry DOI: 10.7270/Q2VH5M71
					More data for this Ligand-Target Pair
MKP-3 (Rattus norvegicus)	BDBM35426 (5-({4-[2-cyano-2-(4-fluorophenyl)vinyl]-2-ethoxyph...) Show SMILES CCOc1cc(\C=C(\C#N)c2ccc(F)cc2)ccc1OCc1ccc(o1)C(O)=O Show InChI InChI=1S/C23H18FNO5/c1-2-28-22-12-15(11-17(13-25)16-4-6-18(24)7-5-16)3-9-20(22)29-14-19-8-10-21(30-19)23(26)27/h3-12H,2,14H2,1H3,(H,26,27)/b17-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Molecular Library Screening Center Curated by PubChem BioAssay					Assay Description The in vitro MKP-3 Phosphatase dose response hit/probe assessment assay has been developed and run at the University of Pittsburgh Molecular Screenin...				PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2H70D6B
					More data for this Ligand-Target Pair
leucine aminopeptidase (Plasmodium falciparum 3D7)	BDBM35426 (5-({4-[2-cyano-2-(4-fluorophenyl)vinyl]-2-ethoxyph...) Show SMILES CCOc1cc(\C=C(\C#N)c2ccc(F)cc2)ccc1OCc1ccc(o1)C(O)=O Show InChI InChI=1S/C23H18FNO5/c1-2-28-22-12-15(11-17(13-25)16-4-6-18(24)7-5-16)3-9-20(22)29-14-19-8-10-21(30-19)23(26)27/h3-12H,2,14H2,1H3,(H,26,27)/b17-11-	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	2.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC Curated by PubChem BioAssay					Assay Description Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q27W69N8
					More data for this Ligand-Target Pair
MKP-3 (Rattus norvegicus)	BDBM35426 (5-({4-[2-cyano-2-(4-fluorophenyl)vinyl]-2-ethoxyph...) Show SMILES CCOc1cc(\C=C(\C#N)c2ccc(F)cc2)ccc1OCc1ccc(o1)C(O)=O Show InChI InChI=1S/C23H18FNO5/c1-2-28-22-12-15(11-17(13-25)16-4-6-18(24)7-5-16)3-9-20(22)29-14-19-8-10-21(30-19)23(26)27/h3-12H,2,14H2,1H3,(H,26,27)/b17-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Molecular Library Screening Center Curated by PubChem BioAssay					Assay Description The MKP-3 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-3...				PubChem Bioassay (2006) BindingDB Entry DOI: 10.7270/Q2M043S8
					More data for this Ligand-Target Pair
MKP-3 (Rattus norvegicus)	BDBM35426 (5-({4-[2-cyano-2-(4-fluorophenyl)vinyl]-2-ethoxyph...) Show SMILES CCOc1cc(\C=C(\C#N)c2ccc(F)cc2)ccc1OCc1ccc(o1)C(O)=O Show InChI InChI=1S/C23H18FNO5/c1-2-28-22-12-15(11-17(13-25)16-4-6-18(24)7-5-16)3-9-20(22)29-14-19-8-10-21(30-19)23(26)27/h3-12H,2,14H2,1H3,(H,26,27)/b17-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Molecular Library Screening Center Curated by PubChem BioAssay					Assay Description The MKP-3 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-3 inhibit...				PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2G73C2Z
					More data for this Ligand-Target Pair
Dual specificity phosphatase Cdc25B (Homo sapiens (Human))	BDBM35426 (5-({4-[2-cyano-2-(4-fluorophenyl)vinyl]-2-ethoxyph...) Show SMILES CCOc1cc(\C=C(\C#N)c2ccc(F)cc2)ccc1OCc1ccc(o1)C(O)=O Show InChI InChI=1S/C23H18FNO5/c1-2-28-22-12-15(11-17(13-25)16-4-6-18(24)7-5-16)3-9-20(22)29-14-19-8-10-21(30-19)23(26)27/h3-12H,2,14H2,1H3,(H,26,27)/b17-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Molecular Library Screening Center Curated by PubChem BioAssay					Assay Description The MKP-1 Dual Specificity Protein Tyrosine Phosphatase Probe Assessment Cdc25B Dose Response Selectivity Assay has been developed to evaluate the PT...				PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2125R2H
					More data for this Ligand-Target Pair
Dual Specificity Protein Phosphatase 1 (Homo sapiens (Human))	BDBM35426 (5-({4-[2-cyano-2-(4-fluorophenyl)vinyl]-2-ethoxyph...) Show SMILES CCOc1cc(\C=C(\C#N)c2ccc(F)cc2)ccc1OCc1ccc(o1)C(O)=O Show InChI InChI=1S/C23H18FNO5/c1-2-28-22-12-15(11-17(13-25)16-4-6-18(24)7-5-16)3-9-20(22)29-14-19-8-10-21(30-19)23(26)27/h3-12H,2,14H2,1H3,(H,26,27)/b17-11-	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	3.67E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Molecular Library Screening Center Curated by PubChem BioAssay					Assay Description The MKP-1 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-1 inhibit...				PubChem Bioassay (2006) BindingDB Entry DOI: 10.7270/Q2QR4VH9
					More data for this Ligand-Target Pair