null

SMILES: C[C@H](NC(=O)N1CCN(CC1)c1ncnc2cc(sc12)C1=CC(C)(C)NC(C)(C)C1)c1cccc(Cl)c1

InChI Key: InChIKey=HIRNPSJKSHGRSC-SFHVURJKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369255   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM369255 (N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6- (2,2,6,6-te...) Show SMILES C[C@H](NC(=O)N1CCN(CC1)c1ncnc2cc(sc12)C1=CC(C)(C)NC(C)(C)C1)c1cccc(Cl)c1 |r,t:23| Show InChI InChI=1S/C28H35ClN6OS/c1-18(19-7-6-8-21(29)13-19)32-26(36)35-11-9-34(10-12-35)25-24-22(30-17-31-25)14-23(37-24)20-15-27(2,3)33-28(4,5)16-20/h6-8,13-15,17-18,33H,9-12,16H2,1-5H3,(H,32,36)/t18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universitàadi Roma					Assay Description The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...				J Med Chem 51: 1560-76 (2008) BindingDB Entry DOI: 10.7270/Q2HX1FZW
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM369255 (N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6- (2,2,6,6-te...) Show SMILES C[C@H](NC(=O)N1CCN(CC1)c1ncnc2cc(sc12)C1=CC(C)(C)NC(C)(C)C1)c1cccc(Cl)c1 |r,t:23| Show InChI InChI=1S/C28H35ClN6OS/c1-18(19-7-6-8-21(29)13-19)32-26(36)35-11-9-34(10-12-35)25-24-22(30-17-31-25)14-23(37-24)20-15-27(2,3)33-28(4,5)16-20/h6-8,13-15,17-18,33H,9-12,16H2,1-5H3,(H,32,36)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.05E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universitàadi Roma					Assay Description The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...				J Med Chem 51: 1560-76 (2008) BindingDB Entry DOI: 10.7270/Q2HX1FZW
					More data for this Ligand-Target Pair