null

SMILES: Cc1nn(C)cc1-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(Cl)cc1

InChI Key: InChIKey=ZTBFFRNCHRMIBF-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369351   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM369351 (4-chloro-N-[1-[6-(1,3-dimethylpyrazol- 4-yl)-7H-py...) Show SMILES Cc1nn(C)cc1-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H24ClN7O2S/c1-14-19(12-29(2)27-14)20-11-18-21(26-20)24-13-25-22(18)30-9-7-16(8-10-30)28-33(31,32)17-5-3-15(23)4-6-17/h3-6,11-13,16,28H,7-10H2,1-2H3,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universitàadi Roma					Assay Description The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...				J Med Chem 51: 1560-76 (2008) BindingDB Entry DOI: 10.7270/Q2HX1FZW
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM369351 (4-chloro-N-[1-[6-(1,3-dimethylpyrazol- 4-yl)-7H-py...) Show SMILES Cc1nn(C)cc1-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H24ClN7O2S/c1-14-19(12-29(2)27-14)20-11-18-21(26-20)24-13-25-22(18)30-9-7-16(8-10-30)28-33(31,32)17-5-3-15(23)4-6-17/h3-6,11-13,16,28H,7-10H2,1-2H3,(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universitàadi Roma					Assay Description The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...				J Med Chem 51: 1560-76 (2008) BindingDB Entry DOI: 10.7270/Q2HX1FZW
					More data for this Ligand-Target Pair