BDBM376073 3-(1-methyl-1H-pyrazol-3-yl)- N-[5'-methyl-3-(pyrrolidin-1- ylmethyl)-2'H-1,3'-bipyrazol- 5-yl]-4- (trifluoromethyl)benzamide::US9914736, Compound 69
SMILES: Cc1cc([nH]n1)-n1nc(CN2CCCC2)cc1NC(=O)c1ccc(c(c1)-c1ccn(C)n1)C(F)(F)F
InChI Key: InChIKey=SJEDFGACGRUFPQ-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM376073![]() (3-(1-methyl-1H-pyrazol-3-yl)- N-[5'-methyl-3-(pyrr...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur | Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal... | J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629 | |||||||||||
More data for this Ligand-Target Pair |