Found 8 hits for monomerid = 385045 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM385045
(US10287267, Compound 6 | US10508099, Compound 6 | ...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)[C@H]3CC[C@@H](CC3)N3CCOCC3)cc2c1 |r,wU:19.23,wD:16.16,(-9.72,2.58,;-8.95,1.25,;-7.48,.77,;-7.48,-.77,;-8.95,-1.25,;-9.85,,;-6.15,-1.54,;-6.15,-3.08,;-4.82,-3.85,;-3.48,-3.08,;-2.15,-3.85,;-.82,-3.08,;-.82,-1.54,;.52,-.77,;1.85,-1.54,;1.85,-3.08,;3.19,-.77,;4.52,-1.54,;5.85,-.77,;5.85,.77,;4.52,1.54,;3.19,.77,;7.19,1.54,;8.52,.77,;9.85,1.54,;9.85,3.08,;8.52,3.85,;7.19,3.08,;-2.15,-.77,;-3.48,-1.54,;-4.82,-.77,)| Show InChI InChI=1S/C24H29N5O2/c1-28-16-21(15-26-28)18-2-3-19-14-25-23(13-20(19)12-18)27-24(30)17-4-6-22(7-5-17)29-8-10-31-11-9-29/h2-3,12-17,22H,4-11H2,1H3,(H,25,27,30)/t17-,22- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 65 | n/a | n/a | n/a | n/a |
Novartis
| Assay Description
Each compound is dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves f... |
J Med Chem 51: 7049-52 (2008)
BindingDB Entry DOI: 10.7270/Q2MS3W3C |
More data for this
Ligand-Target Pair | |
Proto-oncogene Wnt-1
(Homo sapiens (human)) | BDBM385045
(US10287267, Compound 6 | US10508099, Compound 6 | ...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)[C@H]3CC[C@@H](CC3)N3CCOCC3)cc2c1 |r,wU:19.23,wD:16.16,(-9.72,2.58,;-8.95,1.25,;-7.48,.77,;-7.48,-.77,;-8.95,-1.25,;-9.85,,;-6.15,-1.54,;-6.15,-3.08,;-4.82,-3.85,;-3.48,-3.08,;-2.15,-3.85,;-.82,-3.08,;-.82,-1.54,;.52,-.77,;1.85,-1.54,;1.85,-3.08,;3.19,-.77,;4.52,-1.54,;5.85,-.77,;5.85,.77,;4.52,1.54,;3.19,.77,;7.19,1.54,;8.52,.77,;9.85,1.54,;9.85,3.08,;8.52,3.85,;7.19,3.08,;-2.15,-.77,;-3.48,-1.54,;-4.82,-.77,)| Show InChI InChI=1S/C24H29N5O2/c1-28-16-21(15-26-28)18-2-3-19-14-25-23(13-20(19)12-18)27-24(30)17-4-6-22(7-5-17)29-8-10-31-11-9-29/h2-3,12-17,22H,4-11H2,1H3,(H,25,27,30)/t17-,22- | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.11E+3 | n/a | n/a | n/a | n/a |
Novartis
| Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col... |
J Med Chem 51: 7049-52 (2008)
BindingDB Entry DOI: 10.7270/Q2MS3W3C |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM385045
(US10287267, Compound 6 | US10508099, Compound 6 | ...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)[C@H]3CC[C@@H](CC3)N3CCOCC3)cc2c1 |r,wU:19.23,wD:16.16,(-9.72,2.58,;-8.95,1.25,;-7.48,.77,;-7.48,-.77,;-8.95,-1.25,;-9.85,,;-6.15,-1.54,;-6.15,-3.08,;-4.82,-3.85,;-3.48,-3.08,;-2.15,-3.85,;-.82,-3.08,;-.82,-1.54,;.52,-.77,;1.85,-1.54,;1.85,-3.08,;3.19,-.77,;4.52,-1.54,;5.85,-.77,;5.85,.77,;4.52,1.54,;3.19,.77,;7.19,1.54,;8.52,.77,;9.85,1.54,;9.85,3.08,;8.52,3.85,;7.19,3.08,;-2.15,-.77,;-3.48,-1.54,;-4.82,-.77,)| Show InChI InChI=1S/C24H29N5O2/c1-28-16-21(15-26-28)18-2-3-19-14-25-23(13-20(19)12-18)27-24(30)17-4-6-22(7-5-17)29-8-10-31-11-9-29/h2-3,12-17,22H,4-11H2,1H3,(H,25,27,30)/t17-,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
Novartis
| Assay Description
Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ... |
J Med Chem 51: 7049-52 (2008)
BindingDB Entry DOI: 10.7270/Q2MS3W3C |
More data for this
Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM385045
(US10287267, Compound 6 | US10508099, Compound 6 | ...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)[C@H]3CC[C@@H](CC3)N3CCOCC3)cc2c1 |r,wU:19.23,wD:16.16,(-9.72,2.58,;-8.95,1.25,;-7.48,.77,;-7.48,-.77,;-8.95,-1.25,;-9.85,,;-6.15,-1.54,;-6.15,-3.08,;-4.82,-3.85,;-3.48,-3.08,;-2.15,-3.85,;-.82,-3.08,;-.82,-1.54,;.52,-.77,;1.85,-1.54,;1.85,-3.08,;3.19,-.77,;4.52,-1.54,;5.85,-.77,;5.85,.77,;4.52,1.54,;3.19,.77,;7.19,1.54,;8.52,.77,;9.85,1.54,;9.85,3.08,;8.52,3.85,;7.19,3.08,;-2.15,-.77,;-3.48,-1.54,;-4.82,-.77,)| Show InChI InChI=1S/C24H29N5O2/c1-28-16-21(15-26-28)18-2-3-19-14-25-23(13-20(19)12-18)27-24(30)17-4-6-22(7-5-17)29-8-10-31-11-9-29/h2-3,12-17,22H,4-11H2,1H3,(H,25,27,30)/t17-,22- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 65 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM385045
(US10287267, Compound 6 | US10508099, Compound 6 | ...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)[C@H]3CC[C@@H](CC3)N3CCOCC3)cc2c1 |r,wU:19.23,wD:16.16,(-9.72,2.58,;-8.95,1.25,;-7.48,.77,;-7.48,-.77,;-8.95,-1.25,;-9.85,,;-6.15,-1.54,;-6.15,-3.08,;-4.82,-3.85,;-3.48,-3.08,;-2.15,-3.85,;-.82,-3.08,;-.82,-1.54,;.52,-.77,;1.85,-1.54,;1.85,-3.08,;3.19,-.77,;4.52,-1.54,;5.85,-.77,;5.85,.77,;4.52,1.54,;3.19,.77,;7.19,1.54,;8.52,.77,;9.85,1.54,;9.85,3.08,;8.52,3.85,;7.19,3.08,;-2.15,-.77,;-3.48,-1.54,;-4.82,-.77,)| Show InChI InChI=1S/C24H29N5O2/c1-28-16-21(15-26-28)18-2-3-19-14-25-23(13-20(19)12-18)27-24(30)17-4-6-22(7-5-17)29-8-10-31-11-9-29/h2-3,12-17,22H,4-11H2,1H3,(H,25,27,30)/t17-,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
Samumed, LLC
US Patent
| Assay Description
Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ... |
US Patent US10508099 (2019)
BindingDB Entry DOI: 10.7270/Q2DJ5J0C |
More data for this
Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM385045
(US10287267, Compound 6 | US10508099, Compound 6 | ...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)[C@H]3CC[C@@H](CC3)N3CCOCC3)cc2c1 |r,wU:19.23,wD:16.16,(-9.72,2.58,;-8.95,1.25,;-7.48,.77,;-7.48,-.77,;-8.95,-1.25,;-9.85,,;-6.15,-1.54,;-6.15,-3.08,;-4.82,-3.85,;-3.48,-3.08,;-2.15,-3.85,;-.82,-3.08,;-.82,-1.54,;.52,-.77,;1.85,-1.54,;1.85,-3.08,;3.19,-.77,;4.52,-1.54,;5.85,-.77,;5.85,.77,;4.52,1.54,;3.19,.77,;7.19,1.54,;8.52,.77,;9.85,1.54,;9.85,3.08,;8.52,3.85,;7.19,3.08,;-2.15,-.77,;-3.48,-1.54,;-4.82,-.77,)| Show InChI InChI=1S/C24H29N5O2/c1-28-16-21(15-26-28)18-2-3-19-14-25-23(13-20(19)12-18)27-24(30)17-4-6-22(7-5-17)29-8-10-31-11-9-29/h2-3,12-17,22H,4-11H2,1H3,(H,25,27,30)/t17-,22- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 65 | n/a | n/a | n/a | n/a |
Samumed, LLC
US Patent
| Assay Description
Each compound is dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves f... |
US Patent US10508099 (2019)
BindingDB Entry DOI: 10.7270/Q2DJ5J0C |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM385045
(US10287267, Compound 6 | US10508099, Compound 6 | ...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)[C@H]3CC[C@@H](CC3)N3CCOCC3)cc2c1 |r,wU:19.23,wD:16.16,(-9.72,2.58,;-8.95,1.25,;-7.48,.77,;-7.48,-.77,;-8.95,-1.25,;-9.85,,;-6.15,-1.54,;-6.15,-3.08,;-4.82,-3.85,;-3.48,-3.08,;-2.15,-3.85,;-.82,-3.08,;-.82,-1.54,;.52,-.77,;1.85,-1.54,;1.85,-3.08,;3.19,-.77,;4.52,-1.54,;5.85,-.77,;5.85,.77,;4.52,1.54,;3.19,.77,;7.19,1.54,;8.52,.77,;9.85,1.54,;9.85,3.08,;8.52,3.85,;7.19,3.08,;-2.15,-.77,;-3.48,-1.54,;-4.82,-.77,)| Show InChI InChI=1S/C24H29N5O2/c1-28-16-21(15-26-28)18-2-3-19-14-25-23(13-20(19)12-18)27-24(30)17-4-6-22(7-5-17)29-8-10-31-11-9-29/h2-3,12-17,22H,4-11H2,1H3,(H,25,27,30)/t17-,22- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene Wnt-1
(Homo sapiens (human)) | BDBM385045
(US10287267, Compound 6 | US10508099, Compound 6 | ...)Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)[C@H]3CC[C@@H](CC3)N3CCOCC3)cc2c1 |r,wU:19.23,wD:16.16,(-9.72,2.58,;-8.95,1.25,;-7.48,.77,;-7.48,-.77,;-8.95,-1.25,;-9.85,,;-6.15,-1.54,;-6.15,-3.08,;-4.82,-3.85,;-3.48,-3.08,;-2.15,-3.85,;-.82,-3.08,;-.82,-1.54,;.52,-.77,;1.85,-1.54,;1.85,-3.08,;3.19,-.77,;4.52,-1.54,;5.85,-.77,;5.85,.77,;4.52,1.54,;3.19,.77,;7.19,1.54,;8.52,.77,;9.85,1.54,;9.85,3.08,;8.52,3.85,;7.19,3.08,;-2.15,-.77,;-3.48,-1.54,;-4.82,-.77,)| Show InChI InChI=1S/C24H29N5O2/c1-28-16-21(15-26-28)18-2-3-19-14-25-23(13-20(19)12-18)27-24(30)17-4-6-22(7-5-17)29-8-10-31-11-9-29/h2-3,12-17,22H,4-11H2,1H3,(H,25,27,30)/t17-,22- | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.11E+3 | n/a | n/a | n/a | n/a |
Samumed, LLC
US Patent
| Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh... |
US Patent US10508099 (2019)
BindingDB Entry DOI: 10.7270/Q2DJ5J0C |
More data for this
Ligand-Target Pair | |
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