null
SMILES: CN1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
InChI Key: InChIKey=RDXXBKZUEDSZQK-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM385069 (US10287267, Compound 73 | US10508099, Compound 73 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 49 | n/a | n/a | n/a | n/a |
Novartis | Assay Description Each compound is dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves f... | J Med Chem 51: 7049-52 (2008) BindingDB Entry DOI: 10.7270/Q2MS3W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene Wnt-1 (Homo sapiens (human)) | BDBM385069 (US10287267, Compound 73 | US10508099, Compound 73 ...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 485 | n/a | n/a | n/a | n/a |
Novartis | Assay Description The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col... | J Med Chem 51: 7049-52 (2008) BindingDB Entry DOI: 10.7270/Q2MS3W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human)) | BDBM385069 (US10287267, Compound 73 | US10508099, Compound 73 ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a |
Novartis | Assay Description Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ... | J Med Chem 51: 7049-52 (2008) BindingDB Entry DOI: 10.7270/Q2MS3W3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene Wnt-1 (Homo sapiens (human)) | BDBM385069 (US10287267, Compound 73 | US10508099, Compound 73 ...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 485 | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh... | US Patent US10508099 (2019) BindingDB Entry DOI: 10.7270/Q2DJ5J0C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human)) | BDBM385069 (US10287267, Compound 73 | US10508099, Compound 73 ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ... | US Patent US10508099 (2019) BindingDB Entry DOI: 10.7270/Q2DJ5J0C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM385069 (US10287267, Compound 73 | US10508099, Compound 73 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | n/a | n/a | 49 | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human)) | BDBM385069 (US10287267, Compound 73 | US10508099, Compound 73 ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 _... | US Patent US10604514 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM385069 (US10287267, Compound 73 | US10508099, Compound 73 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 53 | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description Briefly, recombinant GSK3β kinase, ATP and Ser/Thr peptide 09 are prepared in 1× Kinase buffer to final concentrations of 0.04 μg/mL, 46 &... | US Patent US10604514 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human)) | BDBM385069 (US10287267, Compound 73 | US10508099, Compound 73 ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions. This is a non-radioactive... | US Patent US10556885 (2020) BindingDB Entry DOI: 10.7270/Q2ZW1P9Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM385069 (US10287267, Compound 73 | US10508099, Compound 73 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 49 | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description GSK3B: This is a non-radioactive assay using fluorescence resonance energy transfer (FRET) between coumarin and fluorescein to detect kinase activity... | US Patent US10556885 (2020) BindingDB Entry DOI: 10.7270/Q2ZW1P9Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human)) | BDBM385069 (US10287267, Compound 73 | US10508099, Compound 73 ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM385069 (US10287267, Compound 73 | US10508099, Compound 73 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 49 | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description Each compound is dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves f... | US Patent US10508099 (2019) BindingDB Entry DOI: 10.7270/Q2DJ5J0C | |||||||||||
More data for this Ligand-Target Pair |