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SMILES: Cc1n[nH]c(C(=O)Nc2cnc(Nc3ccccc3)nc2)c1C

InChI Key: InChIKey=JWFAADHRYYGPOF-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 392395   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM392395 (N-(2-anilinopyrimidin-5-yl)-3,4- dimethyl-1H-pyraz...) Show SMILES Cc1n[nH]c(C(=O)Nc2cnc(Nc3ccccc3)nc2)c1C Show InChI InChI=1S/C16H16N6O/c1-10-11(2)21-22-14(10)15(23)19-13-8-17-16(18-9-13)20-12-6-4-3-5-7-12/h3-9H,1-2H3,(H,19,23)(H,21,22)(H,17,18,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				J Med Chem 52: 1799-802 (2009) BindingDB Entry DOI: 10.7270/Q2HH6NDZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM392395 (N-(2-anilinopyrimidin-5-yl)-3,4- dimethyl-1H-pyraz...) Show SMILES Cc1n[nH]c(C(=O)Nc2cnc(Nc3ccccc3)nc2)c1C Show InChI InChI=1S/C16H16N6O/c1-10-11(2)21-22-14(10)15(23)19-13-8-17-16(18-9-13)20-12-6-4-3-5-7-12/h3-9H,1-2H3,(H,19,23)(H,21,22)(H,17,18,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.05E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				J Med Chem 52: 1799-802 (2009) BindingDB Entry DOI: 10.7270/Q2HH6NDZ
					More data for this Ligand-Target Pair