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SMILES: Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2cnccc2C(N)=O)c1C

InChI Key: InChIKey=RZABNWWGCMXMAO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 392488   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM392488 (3-[5-[(3,4-dimethyl-1H-pyrazole-5- carbonyl)amino]...) Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2cnccc2C(N)=O)c1C Show InChI InChI=1S/C19H17N7O2/c1-9-10(2)25-26-16(9)19(28)23-12-5-11-6-15(24-18(11)22-7-12)14-8-21-4-3-13(14)17(20)27/h3-8H,1-2H3,(H2,20,27)(H,22,24)(H,23,28)(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				J Med Chem 52: 1799-802 (2009) BindingDB Entry DOI: 10.7270/Q2HH6NDZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM392488 (3-[5-[(3,4-dimethyl-1H-pyrazole-5- carbonyl)amino]...) Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2cnccc2C(N)=O)c1C Show InChI InChI=1S/C19H17N7O2/c1-9-10(2)25-26-16(9)19(28)23-12-5-11-6-15(24-18(11)22-7-12)14-8-21-4-3-13(14)17(20)27/h3-8H,1-2H3,(H2,20,27)(H,22,24)(H,23,28)(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.05E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				J Med Chem 52: 1799-802 (2009) BindingDB Entry DOI: 10.7270/Q2HH6NDZ
					More data for this Ligand-Target Pair