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SMILES: Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(Cl)cc2C)c1C

InChI Key: InChIKey=DTIIBNIEFCPILA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 392493   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM392493 (N-[2-(4-chloro-2-methyl-phenyl)- 1H-pyrrolo[2,3-b]...) Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(Cl)cc2C)c1C Show InChI InChI=1S/C20H18ClN5O/c1-10-6-14(21)4-5-16(10)17-8-13-7-15(9-22-19(13)24-17)23-20(27)18-11(2)12(3)25-26-18/h4-9H,1-3H3,(H,22,24)(H,23,27)(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				J Med Chem 52: 1799-802 (2009) BindingDB Entry DOI: 10.7270/Q2HH6NDZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM392493 (N-[2-(4-chloro-2-methyl-phenyl)- 1H-pyrrolo[2,3-b]...) Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(Cl)cc2C)c1C Show InChI InChI=1S/C20H18ClN5O/c1-10-6-14(21)4-5-16(10)17-8-13-7-15(9-22-19(13)24-17)23-20(27)18-11(2)12(3)25-26-18/h4-9H,1-3H3,(H,22,24)(H,23,27)(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.05E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				J Med Chem 52: 1799-802 (2009) BindingDB Entry DOI: 10.7270/Q2HH6NDZ
					More data for this Ligand-Target Pair