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SMILES: Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccncc2Cl)c1C

InChI Key: InChIKey=BYOYRPXBPUSGTH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 392494   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM392494 (N-[2-(3-chloro-4-pyridyl)-1H- pyrrolo[2,3-b]pyridi...) Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccncc2Cl)c1C Show InChI InChI=1S/C18H15ClN6O/c1-9-10(2)24-25-16(9)18(26)22-12-5-11-6-15(23-17(11)21-7-12)13-3-4-20-8-14(13)19/h3-8H,1-2H3,(H,21,23)(H,22,26)(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				J Med Chem 52: 1799-802 (2009) BindingDB Entry DOI: 10.7270/Q2HH6NDZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM392494 (N-[2-(3-chloro-4-pyridyl)-1H- pyrrolo[2,3-b]pyridi...) Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccncc2Cl)c1C Show InChI InChI=1S/C18H15ClN6O/c1-9-10(2)24-25-16(9)18(26)22-12-5-11-6-15(23-17(11)21-7-12)13-3-4-20-8-14(13)19/h3-8H,1-2H3,(H,21,23)(H,22,26)(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.05E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				J Med Chem 52: 1799-802 (2009) BindingDB Entry DOI: 10.7270/Q2HH6NDZ
					More data for this Ligand-Target Pair