BDBM392496 N-[2-(2,6-difluoro-3-pyridyl)-1H- pyrrolo[2,3-b]pyridin-5-yl]-3,4- dimethyl-1H-pyrazole-5- carboxamide::US10301280, Compound P-2280

SMILES: Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(F)nc2F)c1C

InChI Key: InChIKey=FXONDGFHWFUPFH-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 392496   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM392496 (N-[2-(2,6-difluoro-3-pyridyl)-1H- pyrrolo[2,3-b]py...) Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(F)nc2F)c1C Show InChI InChI=1S/C18H14F2N6O/c1-8-9(2)25-26-15(8)18(27)22-11-5-10-6-13(23-17(10)21-7-11)12-3-4-14(19)24-16(12)20/h3-7H,1-2H3,(H,21,23)(H,22,27)(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				J Med Chem 52: 1799-802 (2009) BindingDB Entry DOI: 10.7270/Q2HH6NDZ
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM392496 (N-[2-(2,6-difluoro-3-pyridyl)-1H- pyrrolo[2,3-b]py...) Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(F)nc2F)c1C Show InChI InChI=1S/C18H14F2N6O/c1-8-9(2)25-26-15(8)18(27)22-11-5-10-6-13(23-17(10)21-7-11)12-3-4-14(19)24-16(12)20/h3-7H,1-2H3,(H,21,23)(H,22,27)(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.05E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				J Med Chem 52: 1799-802 (2009) BindingDB Entry DOI: 10.7270/Q2HH6NDZ
					More data for this Ligand-Target Pair