BDBM397812 US9994552, Compound 23::US9994552, Compound 26

SMILES: COc1cc2ncnc(N3CCN(C(C)C3)c3ncc(Cc4ccccc4)cn3)c2cc1OC

InChI Key: InChIKey=XJAAWJQEAXBXCQ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 397812   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM397812 (US9994552, Compound 23 | US9994552, Compound 26) Show SMILES COc1cc2ncnc(N3CCN(C(C)C3)c3ncc(Cc4ccccc4)cn3)c2cc1OC Show InChI InChI=1S/C26H28N6O2/c1-18-16-31(25-21-12-23(33-2)24(34-3)13-22(21)29-17-30-25)9-10-32(18)26-27-14-20(15-28-26)11-19-7-5-4-6-8-19/h4-8,12-15,17-18H,9-11,16H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V) (Homo sapiens (Human))	BDBM397812 (US9994552, Compound 23 | US9994552, Compound 26) Show SMILES COc1cc2ncnc(N3CCN(C(C)C3)c3ncc(Cc4ccccc4)cn3)c2cc1OC Show InChI InChI=1S/C26H28N6O2/c1-18-16-31(25-21-12-23(33-2)24(34-3)13-22(21)29-17-30-25)9-10-32(18)26-27-14-20(15-28-26)11-19-7-5-4-6-8-19/h4-8,12-15,17-18H,9-11,16H2,1-3H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM397812 (US9994552, Compound 23 | US9994552, Compound 26) Show SMILES COc1cc2ncnc(N3CCN(C(C)C3)c3ncc(Cc4ccccc4)cn3)c2cc1OC Show InChI InChI=1S/C26H28N6O2/c1-18-16-31(25-21-12-23(33-2)24(34-3)13-22(21)29-17-30-25)9-10-32(18)26-27-14-20(15-28-26)11-19-7-5-4-6-8-19/h4-8,12-15,17-18H,9-11,16H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V) (Homo sapiens (Human))	BDBM397812 (US9994552, Compound 23 | US9994552, Compound 26) Show SMILES COc1cc2ncnc(N3CCN(C(C)C3)c3ncc(Cc4ccccc4)cn3)c2cc1OC Show InChI InChI=1S/C26H28N6O2/c1-18-16-31(25-21-12-23(33-2)24(34-3)13-22(21)29-17-30-25)9-10-32(18)26-27-14-20(15-28-26)11-19-7-5-4-6-8-19/h4-8,12-15,17-18H,9-11,16H2,1-3H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair