BDBM397825 US9994552, Compound 36

SMILES: COc1cc2ncnc(N3CCN(CC3)c3ncc(COc4ccccc4)cn3)c2cc1OC

InChI Key: InChIKey=ITFGZRVQOSOOBE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 397825   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Kit (Kit)(D816V) (Homo sapiens (Human))	BDBM397825 (US9994552, Compound 36) Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(COc4ccccc4)cn3)c2cc1OC Show InChI InChI=1S/C25H26N6O3/c1-32-22-12-20-21(13-23(22)33-2)28-17-29-24(20)30-8-10-31(11-9-30)25-26-14-18(15-27-25)16-34-19-6-4-3-5-7-19/h3-7,12-15,17H,8-11,16H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM397825 (US9994552, Compound 36) Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(COc4ccccc4)cn3)c2cc1OC Show InChI InChI=1S/C25H26N6O3/c1-32-22-12-20-21(13-23(22)33-2)28-17-29-24(20)30-8-10-31(11-9-30)25-26-14-18(15-27-25)16-34-19-6-4-3-5-7-19/h3-7,12-15,17H,8-11,16H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair