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SMILES: CN1CC(C1)Oc1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cn(C)nn1

InChI Key: InChIKey=QCUOWJIBUBGWNW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 427094   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene Wnt-1 (Homo sapiens (human))	BDBM427094 (US10544128, Compound 66) Show SMILES CN1CC(C1)Oc1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cn(C)nn1 Show InChI InChI=1S/C22H21N7O2/c1-28-11-18(12-28)31-21-9-15(5-6-23-21)22(30)25-20-8-17-7-14(3-4-16(17)10-24-20)19-13-29(2)27-26-19/h3-10,13,18H,11-12H2,1-2H3,(H,24,25,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	47	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM427094 (US10544128, Compound 66) Show SMILES CN1CC(C1)Oc1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cn(C)nn1 Show InChI InChI=1S/C22H21N7O2/c1-28-11-18(12-28)31-21-9-15(5-6-23-21)22(30)25-20-8-17-7-14(3-4-16(17)10-24-20)19-13-29(2)27-26-19/h3-10,13,18H,11-12H2,1-2H3,(H,24,25,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.71E+3	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM427094 (US10544128, Compound 66) Show SMILES CN1CC(C1)Oc1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cn(C)nn1 Show InChI InChI=1S/C22H21N7O2/c1-28-11-18(12-28)31-21-9-15(5-6-23-21)22(30)25-20-8-17-7-14(3-4-16(17)10-24-20)19-13-29(2)27-26-19/h3-10,13,18H,11-12H2,1-2H3,(H,24,25,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.5	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair