null

SMILES: CCOc1cc(cc(OC)c1Cl)C1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O

InChI Key: InChIKey=WIVGLBVPOCFAER-CQSZACIVSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 429768   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
A disintegrin and metalloproteinase with thrombospondin motifs 5 (Homo sapiens (Human))	BDBM429768 ((5R)-5-[3-[4- (4-chloro-3- ethoxy-5- methoxy- phen...) Show SMILES CCOc1cc(cc(OC)c1Cl)C1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O |r| Show InChI InChI=1S/C20H26ClN3O5/c1-3-29-16-11-13(10-15(28-2)18(16)21)12-6-8-24(9-7-12)17(25)5-4-14-19(26)23-20(27)22-14/h10-12,14H,3-9H2,1-2H3,(H2,22,23,26,27)/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For the dose res...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM429768 ((5R)-5-[3-[4- (4-chloro-3- ethoxy-5- methoxy- phen...) Show SMILES CCOc1cc(cc(OC)c1Cl)C1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O |r| Show InChI InChI=1S/C20H26ClN3O5/c1-3-29-16-11-13(10-15(28-2)18(16)21)12-6-8-24(9-7-12)17(25)5-4-14-19(26)23-20(27)22-14/h10-12,14H,3-9H2,1-2H3,(H2,22,23,26,27)/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEMS INC...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429768 ((5R)-5-[3-[4- (4-chloro-3- ethoxy-5- methoxy- phen...) Show SMILES CCOc1cc(cc(OC)c1Cl)C1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O |r| Show InChI InChI=1S/C20H26ClN3O5/c1-3-29-16-11-13(10-15(28-2)18(16)21)12-6-8-24(9-7-12)17(25)5-4-14-19(26)23-20(27)22-14/h10-12,14H,3-9H2,1-2H3,(H2,22,23,26,27)/t14-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair