BDBM451721 3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin-6- yl)pyridin-3-yl)-N- cyclopropylbenzenesulfonamide::US10710978, Compound I-12

SMILES: Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)S(=O)(=O)NC1CC1

InChI Key: InChIKey=QHWXURVXTQGCOB-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 451721   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451721 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)S(=O)(=O)NC1CC1 Show InChI InChI=1S/C23H22N4O3S/c24-22-21(15-4-7-20-16(10-15)8-9-25-23(20)28)12-17(13-26-22)14-2-1-3-19(11-14)31(29,30)27-18-5-6-18/h1-4,7,10-13,18,27H,5-6,8-9H2,(H2,24,26)(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 26 (Homo sapiens (Human))	BDBM451721 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)S(=O)(=O)NC1CC1 Show InChI InChI=1S/C23H22N4O3S/c24-22-21(15-4-7-20-16(10-15)8-9-25-23(20)28)12-17(13-26-22)14-2-1-3-19(11-14)31(29,30)27-18-5-6-18/h1-4,7,10-13,18,27H,5-6,8-9H2,(H2,24,26)(H,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 24 (Homo sapiens (Human))	BDBM451721 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)S(=O)(=O)NC1CC1 Show InChI InChI=1S/C23H22N4O3S/c24-22-21(15-4-7-20-16(10-15)8-9-25-23(20)28)12-17(13-26-22)14-2-1-3-19(11-14)31(29,30)27-18-5-6-18/h1-4,7,10-13,18,27H,5-6,8-9H2,(H2,24,26)(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451721 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)S(=O)(=O)NC1CC1 Show InChI InChI=1S/C23H22N4O3S/c24-22-21(15-4-7-20-16(10-15)8-9-25-23(20)28)12-17(13-26-22)14-2-1-3-19(11-14)31(29,30)27-18-5-6-18/h1-4,7,10-13,18,27H,5-6,8-9H2,(H2,24,26)(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair