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Compile Data Set for Download or QSAR

Found 195 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase 24'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 3.30n/an/an/an/an/an/a



Gachon University

Curated by ChEMBL


Assay Description
Inhibition of human MST3 using MBP as substrate by [gamma-33P]-ATP assay

Eur J Med Chem 163: 453-480 (2019)


Article DOI: 10.1016/j.ejmech.2018.11.037
BindingDB Entry DOI: 10.7270/Q2TQ650N
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 3.30n/an/an/an/an/an/a



Gachon University

Curated by ChEMBL


Assay Description
Inhibition of human MST3 using MBP as substrate by [gamma-33P]-ATP assay

Eur J Med Chem 163: 453-480 (2019)


Article DOI: 10.1016/j.ejmech.2018.11.037
BindingDB Entry DOI: 10.7270/Q2TQ650N
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM4552
PNG
(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)
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n/an/a 3.90n/an/an/an/an/an/a



Center for Molecular Medicine of the Austrian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of STK24

Leukemia 23: 477-85 (2009)


Article DOI: 10.1038/leu.2008.334
BindingDB Entry DOI: 10.7270/Q22Z15R6
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 4.30n/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of human MST3 using MBP as substrate by [gamma-33P]-ATP assay

Eur J Med Chem 161: 456-467 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.052
BindingDB Entry DOI: 10.7270/Q2W380MT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 11.8n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human MST3 using MBP as substrate by [gamma-33P]-ATP assay

Citation and Details

Article DOI: 10.1016/j.bmc.2018.02.022
BindingDB Entry DOI: 10.7270/Q2DJ5KB8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM50148921
PNG
(CHEMBL3770443)
Show SMILES CNc1ncc2cc(-c3ccc(cc3Cl)-c3cccc(C)n3)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 |r,wU:26.27,wD:29.31,(-5.08,.92,;-4.02,1.54,;-2.68,.77,;-2.68,-.77,;-1.33,-1.54,;,-.77,;1.33,-1.54,;2.66,-.77,;4,-1.54,;3.99,-3.08,;5.33,-3.85,;6.66,-3.08,;6.66,-1.54,;5.33,-.77,;5.33,.46,;7.99,-3.86,;9.33,-3.09,;10.66,-3.86,;10.66,-5.4,;9.32,-6.17,;9.32,-7.4,;7.99,-5.4,;2.66,.77,;3.73,1.38,;1.33,1.54,;1.33,3.08,;2.67,3.85,;2.68,5.39,;4.01,6.15,;5.34,5.38,;6.41,5.99,;5.34,3.84,;4,3.07,;,.77,;-1.33,1.54,)|
Show InChI InChI=1S/C25H25ClN6O3/c1-14-4-3-5-21(30-14)15-6-7-18(20(26)9-15)19-8-16-10-29-25(28-2)31-23(16)32(24(19)33)11-22-34-12-17(27)13-35-22/h3-10,17,22H,11-13,27H2,1-2H3,(H,28,29,31)/t17-,22-
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n/an/a 43n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MST3

ACS Med Chem Lett 6: 1241-6 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00398
BindingDB Entry DOI: 10.7270/Q2MP554V
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451730
PNG
(4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Show SMILES CN(C1CC1)S(=O)(=O)c1ccc(c(F)c1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1
Show InChI InChI=1S/C24H23FN4O3S/c1-29(17-3-4-17)33(31,32)18-5-7-19(22(25)12-18)16-11-21(23(26)28-13-16)14-2-6-20-15(10-14)8-9-27-24(20)30/h2,5-7,10-13,17H,3-4,8-9H2,1H3,(H2,26,28)(H,27,30)
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n/an/a 120n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451766
PNG
(4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Show SMILES COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)S(=O)(=O)N(C)C1CC1
Show InChI InChI=1S/C25H26N4O4S/c1-29(18-4-5-18)34(31,32)19-6-8-20(23(13-19)33-2)17-12-22(24(26)28-14-17)15-3-7-21-16(11-15)9-10-27-25(21)30/h3,6-8,11-14,18H,4-5,9-10H2,1-2H3,(H2,26,28)(H,27,30)
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n/an/a 120n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451741
PNG
(N-(4-(6-amino-5-(1-oxo- 1,2,3,4-tetrahydroisoquino...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccc(NS(=O)(=O)C2CC2)cc1F
Show InChI InChI=1S/C23H21FN4O3S/c24-21-11-16(28-32(30,31)17-3-4-17)2-6-18(21)15-10-20(22(25)27-12-15)13-1-5-19-14(9-13)7-8-26-23(19)29/h1-2,5-6,9-12,17,28H,3-4,7-8H2,(H2,25,27)(H,26,29)
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n/an/a 120n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451740
PNG
(N-(4-(6-amino-5-(1-oxo- 1,2,3,4-tetrahydroisoquino...)
Show SMILES COc1cc(NS(=O)(=O)C2CC2)ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1
Show InChI InChI=1S/C24H24N4O4S/c1-32-22-12-17(28-33(30,31)18-4-5-18)3-7-19(22)16-11-21(23(25)27-13-16)14-2-6-20-15(10-14)8-9-26-24(20)29/h2-3,6-7,10-13,18,28H,4-5,8-9H2,1H3,(H2,25,27)(H,26,29)
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n/an/a 550n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451762
PNG
(3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)C#N
Show InChI InChI=1S/C21H16N4O/c22-11-13-2-1-3-14(8-13)17-10-19(20(23)25-12-17)15-4-5-18-16(9-15)6-7-24-21(18)26/h1-5,8-10,12H,6-7H2,(H2,23,25)(H,24,26)
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n/an/a 550n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451721
PNG
(3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)S(=O)(=O)NC1CC1
Show InChI InChI=1S/C23H22N4O3S/c24-22-21(15-4-7-20-16(10-15)8-9-25-23(20)28)12-17(13-26-22)14-2-1-3-19(11-14)31(29,30)27-18-5-6-18/h1-4,7,10-13,18,27H,5-6,8-9H2,(H2,24,26)(H,25,28)
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n/an/a 550n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451722
PNG
(6-(2-amino-5- (benzo[d]thiazol-7-yl)pyridin- 3-yl)...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc2ncsc12
Show InChI InChI=1S/C21H16N4OS/c22-20-17(12-4-5-16-13(8-12)6-7-23-21(16)26)9-14(10-24-20)15-2-1-3-18-19(15)27-11-25-18/h1-5,8-11H,6-7H2,(H2,22,24)(H,23,26)
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n/an/a>900n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451719
PNG
(6-(2-amino-5-(2-fluoro-3- nitrophenyl)pyridin-3-yl...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1F)[N+]([O-])=O
Show InChI InChI=1S/C20H15FN4O3/c21-18-14(2-1-3-17(18)25(27)28)13-9-16(19(22)24-10-13)11-4-5-15-12(8-11)6-7-23-20(15)26/h1-5,8-10H,6-7H2,(H2,22,24)(H,23,26)
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n/an/a>900n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451716
PNG
(3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Show SMILES CCNC(=O)c1ccc(F)c(c1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1
Show InChI InChI=1S/C23H21FN4O2/c1-2-26-22(29)15-4-6-20(24)18(10-15)16-11-19(21(25)28-12-16)13-3-5-17-14(9-13)7-8-27-23(17)30/h3-6,9-12H,2,7-8H2,1H3,(H2,25,28)(H,26,29)(H,27,30)
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n/an/a>900n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451715
PNG
(6-(6-amino-4'-fluoro-[3,3'- bipyridin]-5-yl)-3,4- ...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cnccc1F
Show InChI InChI=1S/C19H15FN4O/c20-17-4-5-22-10-16(17)13-8-15(18(21)24-9-13)11-1-2-14-12(7-11)3-6-23-19(14)25/h1-2,4-5,7-10H,3,6H2,(H2,21,24)(H,23,25)
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n/an/a>900n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451714
PNG
(6-(2-amino-5-(2-chloro-5- nitrophenyl)pyridin-3-yl...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(ccc1Cl)[N+]([O-])=O
Show InChI InChI=1S/C20H15ClN4O3/c21-18-4-2-14(25(27)28)9-16(18)13-8-17(19(22)24-10-13)11-1-3-15-12(7-11)5-6-23-20(15)26/h1-4,7-10H,5-6H2,(H2,22,24)(H,23,26)
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n/an/a>900n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451713
PNG
(6-(2-amino-5-(2- fluorophenyl)pyridin-3-yl)- 3,4-d...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccccc1F
Show InChI InChI=1S/C20H16FN3O/c21-18-4-2-1-3-15(18)14-10-17(19(22)24-11-14)12-5-6-16-13(9-12)7-8-23-20(16)25/h1-6,9-11H,7-8H2,(H2,22,24)(H,23,25)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451711
PNG
(6-(2-amino-5-(2-fluoro-5- nitrophenyl)pyridin-3-yl...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(ccc1F)[N+]([O-])=O
Show InChI InChI=1S/C20H15FN4O3/c21-18-4-2-14(25(27)28)9-16(18)13-8-17(19(22)24-10-13)11-1-3-15-12(7-11)5-6-23-20(15)26/h1-4,7-10H,5-6H2,(H2,22,24)(H,23,26)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451712
PNG
(6-(2-amino-5-(3- nitrophenyl)pyridin-3-yl)-3,4- di...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C20H16N4O3/c21-19-18(13-4-5-17-14(8-13)6-7-22-20(17)25)10-15(11-23-19)12-2-1-3-16(9-12)24(26)27/h1-5,8-11H,6-7H2,(H2,21,23)(H,22,25)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451763
PNG
(6-(2-amino-5-(4- chlorothiazol-5-yl)pyridin-3- yl)...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1scnc1Cl
Show InChI InChI=1S/C17H13ClN4OS/c18-15-14(24-8-22-15)11-6-13(16(19)21-7-11)9-1-2-12-10(5-9)3-4-20-17(12)23/h1-2,5-8H,3-4H2,(H2,19,21)(H,20,23)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451761
PNG
(4-(6-amino-5-(1- oxoisoindolin-5-yl)pyridin-3- yl)...)
Show SMILES CN(C1CC1)S(=O)(=O)c1ccc(c(F)c1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCc2c1
Show InChI InChI=1S/C23H21FN4O3S/c1-28(16-3-4-16)32(30,31)17-5-7-18(21(24)10-17)15-9-20(22(25)26-11-15)13-2-6-19-14(8-13)12-27-23(19)29/h2,5-11,16H,3-4,12H2,1H3,(H2,25,26)(H,27,29)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451755
PNG
(N-(4-(6-amino-5-(1-oxo- 1,2,3,4-tetrahydroisoquino...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccc(NS(=O)(=O)C2CC2)cc1OC1CCCCC1
Show InChI InChI=1S/C29H32N4O4S/c30-28-26(18-6-10-25-19(14-18)12-13-31-29(25)34)15-20(17-32-28)24-11-7-21(33-38(35,36)23-8-9-23)16-27(24)37-22-4-2-1-3-5-22/h6-7,10-11,14-17,22-23,33H,1-5,8-9,12-13H2,(H2,30,32)(H,31,34)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451729
PNG
(6-(2-amino-5-(4- (benzylamino)-2-fluoro-5- nitroph...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(c(NCc2ccccc2)cc1F)[N+]([O-])=O
Show InChI InChI=1S/C27H22FN5O3/c28-23-13-24(31-14-16-4-2-1-3-5-16)25(33(35)36)12-21(23)19-11-22(26(29)32-15-19)17-6-7-20-18(10-17)8-9-30-27(20)34/h1-7,10-13,15,31H,8-9,14H2,(H2,29,32)(H,30,34)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451725
PNG
(6-(2-amino-5-(3-fluoro-5- nitrophenyl)pyridin-3-yl...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(F)cc(c1)[N+]([O-])=O
Show InChI InChI=1S/C20H15FN4O3/c21-15-6-13(7-16(9-15)25(27)28)14-8-18(19(22)24-10-14)11-1-2-17-12(5-11)3-4-23-20(17)26/h1-2,5-10H,3-4H2,(H2,22,24)(H,23,26)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451731
PNG
(4-(2-amino-5-(2-fluoro-5- nitrophenyl)pyridin-3-yl...)
Show SMILES NC(=O)c1ccc(cc1Cl)-c1cc(cnc1N)-c1cc(ccc1F)[N+]([O-])=O
Show InChI InChI=1S/C18H12ClFN4O3/c19-15-6-9(1-3-12(15)18(22)25)14-5-10(8-23-17(14)21)13-7-11(24(26)27)2-4-16(13)20/h1-8H,(H2,21,23)(H2,22,25)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451732
PNG
(4-(2-amino-5-(2-fluoro-5- nitrophenyl)pyridin-3- y...)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(cnc1N)-c1cc(ccc1F)[N+]([O-])=O
Show InChI InChI=1S/C18H13FN4O3/c19-16-6-5-13(23(25)26)8-14(16)12-7-15(17(20)22-9-12)10-1-3-11(4-2-10)18(21)24/h1-9H,(H2,20,22)(H2,21,24)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451733
PNG
(6-(6-amino-2'-fluoro-5'-nitro- [3,3'-bipyridin]-5-...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(cnc1F)[N+]([O-])=O
Show InChI InChI=1S/C19H14FN5O3/c20-17-15(7-13(9-23-17)25(27)28)12-6-16(18(21)24-8-12)10-1-2-14-11(5-10)3-4-22-19(14)26/h1-2,5-9H,3-4H2,(H2,21,24)(H,22,26)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451735
PNG
(6-(2-amino-5-(4-ethynyl-2- fluoro-5-nitrophenyl)py...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(c(cc1F)C#C)[N+]([O-])=O
Show InChI InChI=1S/C22H15FN4O3/c1-2-12-9-19(23)17(10-20(12)27(29)30)15-8-18(21(24)26-11-15)13-3-4-16-14(7-13)5-6-25-22(16)28/h1,3-4,7-11H,5-6H2,(H2,24,26)(H,25,28)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451736
PNG
(4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Show SMILES CN(C1CC1)S(=O)(=O)c1ccc(c(C)c1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1
Show InChI InChI=1S/C25H26N4O3S/c1-15-11-20(33(31,32)29(2)19-4-5-19)6-8-21(15)18-13-23(24(26)28-14-18)16-3-7-22-17(12-16)9-10-27-25(22)30/h3,6-8,11-14,19H,4-5,9-10H2,1-2H3,(H2,26,28)(H,27,30)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451737
PNG
(4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Show SMILES CCOc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)S(=O)(=O)N(C)C1CC1
Show InChI InChI=1S/C26H28N4O4S/c1-3-34-24-14-20(35(32,33)30(2)19-5-6-19)7-9-21(24)18-13-23(25(27)29-15-18)16-4-8-22-17(12-16)10-11-28-26(22)31/h4,7-9,12-15,19H,3,5-6,10-11H2,1-2H3,(H2,27,29)(H,28,31)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451738
PNG
(4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Show SMILES CC(C)Oc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)S(=O)(=O)N(C)C1CC1
Show InChI InChI=1S/C27H30N4O4S/c1-16(2)35-25-14-21(36(33,34)31(3)20-5-6-20)7-9-22(25)19-13-24(26(28)30-15-19)17-4-8-23-18(12-17)10-11-29-27(23)32/h4,7-9,12-16,20H,5-6,10-11H2,1-3H3,(H2,28,30)(H,29,32)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451739
PNG
(4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Show SMILES COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)S(=O)(=O)NC1CC1
Show InChI InChI=1S/C24H24N4O4S/c1-32-22-12-18(33(30,31)28-17-3-4-17)5-7-19(22)16-11-21(23(25)27-13-16)14-2-6-20-15(10-14)8-9-26-24(20)29/h2,5-7,10-13,17,28H,3-4,8-9H2,1H3,(H2,25,27)(H,26,29)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451723
PNG
(6-(2-amino-5-(1-methyl-1H- benzo[d]imidazol-4- yl)...)
Show SMILES C[N]1=CNc2c1cccc2-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1 |t:1|
Show InChI InChI=1S/C22H20N5O/c1-27-12-26-20-16(3-2-4-19(20)27)15-10-18(21(23)25-11-15)13-5-6-17-14(9-13)7-8-24-22(17)28/h2-6,9-12,26H,7-8H2,1H3,(H2,23,25)(H,24,28)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451718
PNG
(6-(6-amino-4'-methoxy-[3,3'- bipyridin]-5-yl)-3,4-...)
Show SMILES COc1ccncc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1
Show InChI InChI=1S/C20H18N4O2/c1-26-18-5-6-22-11-17(18)14-9-16(19(21)24-10-14)12-2-3-15-13(8-12)4-7-23-20(15)25/h2-3,5-6,8-11H,4,7H2,1H3,(H2,21,24)(H,23,25)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451742
PNG
(4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Show SMILES COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)S(=O)(=O)N(C)C1CCCCC1
Show InChI InChI=1S/C28H32N4O4S/c1-32(21-6-4-3-5-7-21)37(34,35)22-9-11-23(26(16-22)36-2)20-15-25(27(29)31-17-20)18-8-10-24-19(14-18)12-13-30-28(24)33/h8-11,14-17,21H,3-7,12-13H2,1-2H3,(H2,29,31)(H,30,33)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451743
PNG
(4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Show SMILES COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)S(=O)(=O)N(C)C1CCOCC1
Show InChI InChI=1S/C27H30N4O5S/c1-31(20-8-11-36-12-9-20)37(33,34)21-4-6-22(25(15-21)35-2)19-14-24(26(28)30-16-19)17-3-5-23-18(13-17)7-10-29-27(23)32/h3-6,13-16,20H,7-12H2,1-2H3,(H2,28,30)(H,29,32)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451744
PNG
(6-(2-amino-5-(2-fluoro-4- nitrophenyl)pyridin-3-yl...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccc(cc1F)[N+]([O-])=O
Show InChI InChI=1S/C20H15FN4O3/c21-18-9-14(25(27)28)2-4-15(18)13-8-17(19(22)24-10-13)11-1-3-16-12(7-11)5-6-23-20(16)26/h1-4,7-10H,5-6H2,(H2,22,24)(H,23,26)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451745
PNG
(6-(2-amino-5- (benzo[d]thiazol-4-yl)pyridin- 3-yl)...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc2scnc12
Show InChI InChI=1S/C21H16N4OS/c22-20-17(12-4-5-16-13(8-12)6-7-23-21(16)26)9-14(10-24-20)15-2-1-3-18-19(15)25-11-27-18/h1-5,8-11H,6-7H2,(H2,22,24)(H,23,26)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451746
PNG
(6-(2-amino-5-(thiazolo[4,5- c]pyridin-7-yl)pyridin...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cncc2ncsc12
Show InChI InChI=1S/C20H15N5OS/c21-19-15(11-1-2-14-12(5-11)3-4-23-20(14)26)6-13(7-24-19)16-8-22-9-17-18(16)27-10-25-17/h1-2,5-10H,3-4H2,(H2,21,24)(H,23,26)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451747
PNG
(6-(2-amino-5-(4- fluorobenzo[d]thiazol-7- yl)pyrid...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccc(F)c2ncsc12
Show InChI InChI=1S/C21H15FN4OS/c22-17-4-3-14(19-18(17)26-10-28-19)13-8-16(20(23)25-9-13)11-1-2-15-12(7-11)5-6-24-21(15)27/h1-4,7-10H,5-6H2,(H2,23,25)(H,24,27)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451748
PNG
(N-(3-(6-amino-5-(1-oxo- 1,2,3,4-tetrahydroisoquino...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(NS(=O)(=O)C2CC2)c1
Show InChI InChI=1S/C23H22N4O3S/c24-22-21(15-4-7-20-16(10-15)8-9-25-23(20)28)12-17(13-26-22)14-2-1-3-18(11-14)27-31(29,30)19-5-6-19/h1-4,7,10-13,19,27H,5-6,8-9H2,(H2,24,26)(H,25,28)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451749
PNG
(6-(2-amino-5-(3-(thiazol-2- yl)phenyl)pyridin-3-yl...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)-c1nccs1
Show InChI InChI=1S/C23H18N4OS/c24-21-20(15-4-5-19-16(11-15)6-7-25-22(19)28)12-18(13-27-21)14-2-1-3-17(10-14)23-26-8-9-29-23/h1-5,8-13H,6-7H2,(H2,24,27)(H,25,28)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451750
PNG
(6-(2-amino-5-(2-methoxy-4- (thiazol-2-yl)phenyl)py...)
Show SMILES COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)-c1nccs1
Show InChI InChI=1S/C24H20N4O2S/c1-30-21-12-16(24-27-8-9-31-24)3-4-18(21)17-11-20(22(25)28-13-17)14-2-5-19-15(10-14)6-7-26-23(19)29/h2-5,8-13H,6-7H2,1H3,(H2,25,28)(H,26,29)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451751
PNG
(4-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Show SMILES COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)C#C
Show InChI InChI=1S/C23H19N3O2/c1-3-14-4-6-18(21(10-14)28-2)17-12-20(22(24)26-13-17)15-5-7-19-16(11-15)8-9-25-23(19)27/h1,4-7,10-13H,8-9H2,2H3,(H2,24,26)(H,25,27)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451752
PNG
(4-(6-amino-5-(2-methyl-1- oxo-1,2,3,4- tetrahydroi...)
Show SMILES CN(C1CC1)S(=O)(=O)c1ccc(c(F)c1)-c1cnc(N)c(c1)-c1ccc2C(=O)N(C)CCc2c1
Show InChI InChI=1S/C25H25FN4O3S/c1-29-10-9-16-11-15(3-7-21(16)25(29)31)22-12-17(14-28-24(22)27)20-8-6-19(13-23(20)26)34(32,33)30(2)18-4-5-18/h3,6-8,11-14,18H,4-5,9-10H2,1-2H3,(H2,27,28)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451753
PNG
(4-(6-amino-5-(4-oxo-3,4- dihydroquinazolin-7- yl)p...)
Show SMILES CN(C1CC1)S(=O)(=O)c1ccc(c(F)c1)-c1cnc(N)c(c1)-c1ccc2c(c1)nc[nH]c2=O
Show InChI InChI=1S/C23H20FN5O3S/c1-29(15-3-4-15)33(31,32)16-5-7-17(20(24)10-16)14-8-19(22(25)26-11-14)13-2-6-18-21(9-13)27-12-28-23(18)30/h2,5-12,15H,3-4H2,1H3,(H2,25,26)(H,27,28,30)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451767
PNG
(6-(2-amino-5-(5- fluorobenzo[d]thiazol-6- yl)pyrid...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc2scnc2cc1F
Show InChI InChI=1S/C21H15FN4OS/c22-17-8-18-19(28-10-26-18)7-15(17)13-6-16(20(23)25-9-13)11-1-2-14-12(5-11)3-4-24-21(14)27/h1-2,5-10H,3-4H2,(H2,23,25)(H,24,27)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451756
PNG
(N-(4-(6-amino-5-(1-oxo- 1,2,3,4-tetrahydroisoquino...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccc(NS(=O)(=O)C2CC2)cc1OCc1ccccc1
Show InChI InChI=1S/C30H28N4O4S/c31-29-27(20-6-10-26-21(14-20)12-13-32-30(26)35)15-22(17-33-29)25-11-7-23(34-39(36,37)24-8-9-24)16-28(25)38-18-19-4-2-1-3-5-19/h1-7,10-11,14-17,24,34H,8-9,12-13,18H2,(H2,31,33)(H,32,35)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 24


(Homo sapiens (Human))		BDBM451757
PNG
(N-(4-(6-amino-5-(1-oxo- 1,2,3,4-tetrahydroisoquino...)
Show SMILES CC(C)Oc1cc(NS(=O)(=O)C2CC2)ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1
Show InChI InChI=1S/C26H28N4O4S/c1-15(2)34-24-13-19(30-35(32,33)20-5-6-20)4-8-21(24)18-12-23(25(27)29-14-18)16-3-7-22-17(11-16)9-10-28-26(22)31/h3-4,7-8,11-15,20,30H,5-6,9-10H2,1-2H3,(H2,27,29)(H,28,31)
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DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair
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