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SMILES: Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cnccc1F

InChI Key: InChIKey=HYPFGHUEIYDXCZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 451715   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451715 (6-(6-amino-4'-fluoro-[3,3'- bipyridin]-5-yl)-3,4- ...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cnccc1F Show InChI InChI=1S/C19H15FN4O/c20-17-4-5-22-10-16(17)13-8-15(18(21)24-9-13)11-1-2-14-12(7-11)3-6-23-19(14)25/h1-2,4-5,7-10H,3,6H2,(H2,21,24)(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 26 (Homo sapiens (Human))	BDBM451715 (6-(6-amino-4'-fluoro-[3,3'- bipyridin]-5-yl)-3,4- ...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cnccc1F Show InChI InChI=1S/C19H15FN4O/c20-17-4-5-22-10-16(17)13-8-15(18(21)24-9-13)11-1-2-14-12(7-11)3-6-23-19(14)25/h1-2,4-5,7-10H,3,6H2,(H2,21,24)(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 24 (Homo sapiens (Human))	BDBM451715 (6-(6-amino-4'-fluoro-[3,3'- bipyridin]-5-yl)-3,4- ...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cnccc1F Show InChI InChI=1S/C19H15FN4O/c20-17-4-5-22-10-16(17)13-8-15(18(21)24-9-13)11-1-2-14-12(7-11)3-6-23-19(14)25/h1-2,4-5,7-10H,3,6H2,(H2,21,24)(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>900	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451715 (6-(6-amino-4'-fluoro-[3,3'- bipyridin]-5-yl)-3,4- ...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cnccc1F Show InChI InChI=1S/C19H15FN4O/c20-17-4-5-22-10-16(17)13-8-15(18(21)24-9-13)11-1-2-14-12(7-11)3-6-23-19(14)25/h1-2,4-5,7-10H,3,6H2,(H2,21,24)(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair