BDBM451711 6-(2-amino-5-(2-fluoro-5- nitrophenyl)pyridin-3-yl)-3,4- dihydroisoquinolin-1(2H)-one::US10710978, Compound I-1

SMILES: Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(ccc1F)[N+]([O-])=O

InChI Key: InChIKey=KGOATVWZWAPATC-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 451711   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451711 (6-(2-amino-5-(2-fluoro-5- nitrophenyl)pyridin-3-yl...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(ccc1F)[N+]([O-])=O Show InChI InChI=1S/C20H15FN4O3/c21-18-4-2-14(25(27)28)9-16(18)13-8-17(19(22)24-10-13)11-1-3-15-12(7-11)5-6-23-20(15)26/h1-4,7-10H,5-6H2,(H2,22,24)(H,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 26 (Homo sapiens (Human))	BDBM451711 (6-(2-amino-5-(2-fluoro-5- nitrophenyl)pyridin-3-yl...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(ccc1F)[N+]([O-])=O Show InChI InChI=1S/C20H15FN4O3/c21-18-4-2-14(25(27)28)9-16(18)13-8-17(19(22)24-10-13)11-1-3-15-12(7-11)5-6-23-20(15)26/h1-4,7-10H,5-6H2,(H2,22,24)(H,23,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>900	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 24 (Homo sapiens (Human))	BDBM451711 (6-(2-amino-5-(2-fluoro-5- nitrophenyl)pyridin-3-yl...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(ccc1F)[N+]([O-])=O Show InChI InChI=1S/C20H15FN4O3/c21-18-4-2-14(25(27)28)9-16(18)13-8-17(19(22)24-10-13)11-1-3-15-12(7-11)5-6-23-20(15)26/h1-4,7-10H,5-6H2,(H2,22,24)(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>900	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451711 (6-(2-amino-5-(2-fluoro-5- nitrophenyl)pyridin-3-yl...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(ccc1F)[N+]([O-])=O Show InChI InChI=1S/C20H15FN4O3/c21-18-4-2-14(25(27)28)9-16(18)13-8-17(19(22)24-10-13)11-1-3-15-12(7-11)5-6-23-20(15)26/h1-4,7-10H,5-6H2,(H2,22,24)(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair