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SMILES: COc1ccncc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1

InChI Key: InChIKey=GLDJXCIDBJCSRK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 451718   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451718 (6-(6-amino-4'-methoxy-[3,3'- bipyridin]-5-yl)-3,4-...) Show SMILES COc1ccncc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C20H18N4O2/c1-26-18-5-6-22-11-17(18)14-9-16(19(21)24-10-14)12-2-3-15-13(8-12)4-7-23-20(15)25/h2-3,5-6,8-11H,4,7H2,1H3,(H2,21,24)(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>900	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 26 (Homo sapiens (Human))	BDBM451718 (6-(6-amino-4'-methoxy-[3,3'- bipyridin]-5-yl)-3,4-...) Show SMILES COc1ccncc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C20H18N4O2/c1-26-18-5-6-22-11-17(18)14-9-16(19(21)24-10-14)12-2-3-15-13(8-12)4-7-23-20(15)25/h2-3,5-6,8-11H,4,7H2,1H3,(H2,21,24)(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 24 (Homo sapiens (Human))	BDBM451718 (6-(6-amino-4'-methoxy-[3,3'- bipyridin]-5-yl)-3,4-...) Show SMILES COc1ccncc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C20H18N4O2/c1-26-18-5-6-22-11-17(18)14-9-16(19(21)24-10-14)12-2-3-15-13(8-12)4-7-23-20(15)25/h2-3,5-6,8-11H,4,7H2,1H3,(H2,21,24)(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451718 (6-(6-amino-4'-methoxy-[3,3'- bipyridin]-5-yl)-3,4-...) Show SMILES COc1ccncc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C20H18N4O2/c1-26-18-5-6-22-11-17(18)14-9-16(19(21)24-10-14)12-2-3-15-13(8-12)4-7-23-20(15)25/h2-3,5-6,8-11H,4,7H2,1H3,(H2,21,24)(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020) BindingDB Entry DOI: 10.7270/Q2J67KZW
					More data for this Ligand-Target Pair