null

SMILES: CCNC(=O)c1ccc(F)c(c1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1

InChI Key: InChIKey=OXGXHAZYCPYPIR-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 451716   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451716 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES CCNC(=O)c1ccc(F)c(c1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C23H21FN4O2/c1-2-26-22(29)15-4-6-20(24)18(10-15)16-11-19(21(25)28-12-16)13-3-5-17-14(9-13)7-8-27-23(17)30/h3-6,9-12H,2,7-8H2,1H3,(H2,25,28)(H,26,29)(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>900	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 26 (Homo sapiens (Human))	BDBM451716 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES CCNC(=O)c1ccc(F)c(c1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C23H21FN4O2/c1-2-26-22(29)15-4-6-20(24)18(10-15)16-11-19(21(25)28-12-16)13-3-5-17-14(9-13)7-8-27-23(17)30/h3-6,9-12H,2,7-8H2,1H3,(H2,25,28)(H,26,29)(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 24 (Homo sapiens (Human))	BDBM451716 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES CCNC(=O)c1ccc(F)c(c1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C23H21FN4O2/c1-2-26-22(29)15-4-6-20(24)18(10-15)16-11-19(21(25)28-12-16)13-3-5-17-14(9-13)7-8-27-23(17)30/h3-6,9-12H,2,7-8H2,1H3,(H2,25,28)(H,26,29)(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>900	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451716 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES CCNC(=O)c1ccc(F)c(c1)-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C23H21FN4O2/c1-2-26-22(29)15-4-6-20(24)18(10-15)16-11-19(21(25)28-12-16)13-3-5-17-14(9-13)7-8-27-23(17)30/h3-6,9-12H,2,7-8H2,1H3,(H2,25,28)(H,26,29)(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair