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SMILES: Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)C#N

InChI Key: InChIKey=SLOIJUIDHUKLRX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 451762   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451762 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)C#N Show InChI InChI=1S/C21H16N4O/c22-11-13-2-1-3-14(8-13)17-10-19(20(23)25-12-17)15-4-5-18-16(9-15)6-7-24-21(18)26/h1-5,8-10,12H,6-7H2,(H2,23,25)(H,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451762 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)C#N Show InChI InChI=1S/C21H16N4O/c22-11-13-2-1-3-14(8-13)17-10-19(20(23)25-12-17)15-4-5-18-16(9-15)6-7-24-21(18)26/h1-5,8-10,12H,6-7H2,(H2,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 24 (Homo sapiens (Human))	BDBM451762 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)C#N Show InChI InChI=1S/C21H16N4O/c22-11-13-2-1-3-14(8-13)17-10-19(20(23)25-12-17)15-4-5-18-16(9-15)6-7-24-21(18)26/h1-5,8-10,12H,6-7H2,(H2,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 26 (Homo sapiens (Human))	BDBM451762 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)C#N Show InChI InChI=1S/C21H16N4O/c22-11-13-2-1-3-14(8-13)17-10-19(20(23)25-12-17)15-4-5-18-16(9-15)6-7-24-21(18)26/h1-5,8-10,12H,6-7H2,(H2,23,25)(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451762 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)C#N Show InChI InChI=1S/C21H16N4O/c22-11-13-2-1-3-14(8-13)17-10-19(20(23)25-12-17)15-4-5-18-16(9-15)6-7-24-21(18)26/h1-5,8-10,12H,6-7H2,(H2,23,25)(H,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451762 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)C#N Show InChI InChI=1S/C21H16N4O/c22-11-13-2-1-3-14(8-13)17-10-19(20(23)25-12-17)15-4-5-18-16(9-15)6-7-24-21(18)26/h1-5,8-10,12H,6-7H2,(H2,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 24 (Homo sapiens (Human))	BDBM451762 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)C#N Show InChI InChI=1S/C21H16N4O/c22-11-13-2-1-3-14(8-13)17-10-19(20(23)25-12-17)15-4-5-18-16(9-15)6-7-24-21(18)26/h1-5,8-10,12H,6-7H2,(H2,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 26 (Homo sapiens (Human))	BDBM451762 (3-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...) Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1)C#N Show InChI InChI=1S/C21H16N4O/c22-11-13-2-1-3-14(8-13)17-10-19(20(23)25-12-17)15-4-5-18-16(9-15)6-7-24-21(18)26/h1-5,8-10,12H,6-7H2,(H2,23,25)(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair