BDBM451764 6-(2-amino-5-(4- chlorothiazol-5-yl)pyridin-3- yl)-3,4-dihydroisoquinolin- 1(2H)-one::US10710978, Compound I-77

SMILES: CN1CCc2cc(ccc2C1=O)-c1cc(cnc1N)-c1cccc2ncsc12

InChI Key: InChIKey=UBUSVPVKMAQGRH-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 451764   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase 4 (Homo sapiens (Human))	BDBM451764 (6-(2-amino-5-(4- chlorothiazol-5-yl)pyridin-3- yl)...) Show SMILES CN1CCc2cc(ccc2C1=O)-c1cc(cnc1N)-c1cccc2ncsc12 Show InChI InChI=1S/C22H18N4OS/c1-26-8-7-14-9-13(5-6-17(14)22(26)27)18-10-15(11-24-21(18)23)16-3-2-4-19-20(16)28-12-25-19/h2-6,9-12H,7-8H2,1H3,(H2,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 26 (Homo sapiens (Human))	BDBM451764 (6-(2-amino-5-(4- chlorothiazol-5-yl)pyridin-3- yl)...) Show SMILES CN1CCc2cc(ccc2C1=O)-c1cc(cnc1N)-c1cccc2ncsc12 Show InChI InChI=1S/C22H18N4OS/c1-26-8-7-14-9-13(5-6-17(14)22(26)27)18-10-15(11-24-21(18)23)16-3-2-4-19-20(16)28-12-25-19/h2-6,9-12H,7-8H2,1H3,(H2,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 24 (Homo sapiens (Human))	BDBM451764 (6-(2-amino-5-(4- chlorothiazol-5-yl)pyridin-3- yl)...) Show SMILES CN1CCc2cc(ccc2C1=O)-c1cc(cnc1N)-c1cccc2ncsc12 Show InChI InChI=1S/C22H18N4OS/c1-26-8-7-14-9-13(5-6-17(14)22(26)27)18-10-15(11-24-21(18)23)16-3-2-4-19-20(16)28-12-25-19/h2-6,9-12H,7-8H2,1H3,(H2,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM451764 (6-(2-amino-5-(4- chlorothiazol-5-yl)pyridin-3- yl)...) Show SMILES CN1CCc2cc(ccc2C1=O)-c1cc(cnc1N)-c1cccc2ncsc12 Show InChI InChI=1S/C22H18N4OS/c1-26-8-7-14-9-13(5-6-17(14)22(26)27)18-10-15(11-24-21(18)23)16-3-2-4-19-20(16)28-12-25-19/h2-6,9-12H,7-8H2,1H3,(H2,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE US Patent					Assay Description Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...				US Patent US10710978 (2020)
					More data for this Ligand-Target Pair