BDBM481106 US10906896, Cpd 103

SMILES: CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncc(c3)C3=NN=C(C3)C(=O)Nc3ccnc(C)c3)c2)CC1

InChI Key: InChIKey=MRAGPKBXJJGPCW-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 481106   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM481106 (US10906896, Cpd 103) Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncc(c3)C3=NN=C(C3)C(=O)Nc3ccnc(C)c3)c2)CC1 |c:39,t:37| Show InChI InChI=1S/C39H39N11O2/c1-25-4-9-31(43-37(51)28-7-5-27(6-8-28)24-50-16-14-49(3)15-17-50)20-34(25)46-39-42-13-11-33(45-39)29-19-30(23-40-22-29)35-21-36(48-47-35)38(52)44-32-10-12-41-26(2)18-32/h4-13,18-20,22-23H,14-17,21,24H2,1-3H3,(H,43,51)(H,41,44,52)(H,42,45,46)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Inhibikase Therapeutics, Inc. US Patent					Assay Description Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl2 2 mM DTT) and Stop buffer, (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Re...				US Patent US10906896 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM481106 (US10906896, Cpd 103) Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncc(c3)C3=NN=C(C3)C(=O)Nc3ccnc(C)c3)c2)CC1 |c:39,t:37| Show InChI InChI=1S/C39H39N11O2/c1-25-4-9-31(43-37(51)28-7-5-27(6-8-28)24-50-16-14-49(3)15-17-50)20-34(25)46-39-42-13-11-33(45-39)29-19-30(23-40-22-29)35-21-36(48-47-35)38(52)44-32-10-12-41-26(2)18-32/h4-13,18-20,22-23H,14-17,21,24H2,1-3H3,(H,43,51)(H,41,44,52)(H,42,45,46)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Inhibikase Therapeutics, Inc. US Patent					Assay Description Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl2 2 mM DTT) and Stop buffer, (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Re...				US Patent US10906896 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL2 (Homo sapiens (Human))	BDBM481106 (US10906896, Cpd 103) Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncc(c3)C3=NN=C(C3)C(=O)Nc3ccnc(C)c3)c2)CC1 |c:39,t:37| Show InChI InChI=1S/C39H39N11O2/c1-25-4-9-31(43-37(51)28-7-5-27(6-8-28)24-50-16-14-49(3)15-17-50)20-34(25)46-39-42-13-11-33(45-39)29-19-30(23-40-22-29)35-21-36(48-47-35)38(52)44-32-10-12-41-26(2)18-32/h4-13,18-20,22-23H,14-17,21,24H2,1-3H3,(H,43,51)(H,41,44,52)(H,42,45,46)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	212	n/a	n/a	n/a	n/a	n/a	n/a
Inhibikase Therapeutics, Inc. US Patent					Assay Description Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl2 2 mM DTT) and Stop buffer, (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Re...				US Patent US10906896 (2021)
					More data for this Ligand-Target Pair