BDBM49829 (2-fluorophenyl)(5-(2-(methylamino)thiazol-4-yl)indolin-1-yl)methanone (Compound 1)::(2-fluorophenyl)-[5-[2-(methylamino)-1,3-thiazol-4-yl]-2,3-dihydroindol-1-yl]methanone::(2-fluorophenyl)-[5-[2-(methylamino)-4-thiazolyl]-2,3-dihydroindol-1-yl]methanone::(2-fluorophenyl)-[5-[2-(methylamino)thiazol-4-yl]indolin-1-yl]methanone::MLS000718316::SMR000290584::cid_1450294

SMILES: CNc1nc(cs1)-c1ccc2N(CCc2c1)C(=O)c1ccccc1F

InChI Key: InChIKey=DAKHCIUKYFQQEU-UHFFFAOYSA-N

Data: 3 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 49829   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear factor NF-kappa-B (Homo sapiens (Human))	BDBM49829 ((2-fluorophenyl)(5-(2-(methylamino)thiazol-4-yl)in...) Show SMILES CNc1nc(cs1)-c1ccc2N(CCc2c1)C(=O)c1ccccc1F Show InChI InChI=1S/C19H16FN3OS/c1-21-19-22-16(11-25-19)12-6-7-17-13(10-12)8-9-23(17)18(24)14-4-2-3-5-15(14)20/h2-7,10-11H,8-9H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PCBioAssay	n/a	n/a	n/a	n/a	2.66E+3	n/a	n/a	n/a	n/a
SRMLSC Curated by PubChem BioAssay					Assay Description Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q27P8WT7
					More data for this Ligand-Target Pair
With-No-Lysine kinase 1 (WNK1) (Homo sapiens (Human))	BDBM49829 ((2-fluorophenyl)(5-(2-(methylamino)thiazol-4-yl)in...) Show SMILES CNc1nc(cs1)-c1ccc2N(CCc2c1)C(=O)c1ccccc1F Show InChI InChI=1S/C19H16FN3OS/c1-21-19-22-16(11-25-19)12-6-7-17-13(10-12)8-9-23(17)18(24)14-4-2-3-5-15(14)20/h2-7,10-11H,8-9H2,1H3,(H,21,22)	GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research, Inc.					Assay Description For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 &#...				ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ
					More data for this Ligand-Target Pair
With-No-Lysine kinase 1 (WNK1) (Homo sapiens (Human))	BDBM49829 ((2-fluorophenyl)(5-(2-(methylamino)thiazol-4-yl)in...) Show SMILES CNc1nc(cs1)-c1ccc2N(CCc2c1)C(=O)c1ccccc1F Show InChI InChI=1S/C19H16FN3OS/c1-21-19-22-16(11-25-19)12-6-7-17-13(10-12)8-9-23(17)18(24)14-4-2-3-5-15(14)20/h2-7,10-11H,8-9H2,1H3,(H,21,22)	GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research, Inc.					Assay Description For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 &#...				ACS Chem Biol 11: 3338-3346 (2016) Article DOI: 10.1021/acschembio.6b00511 BindingDB Entry DOI: 10.7270/Q2FB51SQ
					More data for this Ligand-Target Pair
Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 (Homo sapiens (Human))	BDBM49829 ((2-fluorophenyl)(5-(2-(methylamino)thiazol-4-yl)in...) Show SMILES CNc1nc(cs1)-c1ccc2N(CCc2c1)C(=O)c1ccccc1F Show InChI InChI=1S/C19H16FN3OS/c1-21-19-22-16(11-25-19)12-6-7-17-13(10-12)8-9-23(17)18(24)14-4-2-3-5-15(14)20/h2-7,10-11H,8-9H2,1H3,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PCBioAssay	n/a	n/a	>9.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay									PubChem Bioassay (2012) BindingDB Entry DOI: 10.7270/Q2HM5725
					More data for this Ligand-Target Pair