BDBM50000214 CHEMBL337862
SMILES: C(Nc1ccccc1-c1ccccc1)C1=NCCN1
InChI Key: InChIKey=RJDGUOVDCSODNG-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Imidazoline I1 (RAT) | BDBM50000214![]() (CHEMBL337862) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article | 0.933 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to I1 imidazoline binding site in Rattus norvegicus (rat) PC12 cells | Citation and Details Article DOI: 10.1007/s00044-004-0023-9 BindingDB Entry DOI: 10.7270/Q2FJ2KNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Imidazoline I1 (RAT) | BDBM50000214![]() (CHEMBL337862) | UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Displacement of [125I]-p-iodoclonidine from I1 receptor imidazoline binding site in Sprague-Dawley rat kidney cell membranes after 30 mins by liquid ... | ACS Med Chem Lett 7: 956-961 (2016) Article DOI: 10.1021/acsmedchemlett.6b00290 BindingDB Entry DOI: 10.7270/Q2086784 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50000214![]() (CHEMBL337862) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | 355 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Camerino Curated by ChEMBL | Assay Description Displacement of [3H]clonidine from Alpha-2 adrenergic receptor of rat cortex membrane | J Med Chem 45: 32-40 (2002) Article DOI: 10.1021/jm0110082 BindingDB Entry DOI: 10.7270/Q21N83VZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Imidazoline I2-receptor (Homo sapiens (Human)) | BDBM50000214![]() (CHEMBL337862) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | 813 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Camerino Curated by ChEMBL | Assay Description Displacement of [3H]idazoxan from imidazoline receptor I-2 binding sites in rabbit kidney membrane | J Med Chem 45: 32-40 (2002) Article DOI: 10.1021/jm0110082 BindingDB Entry DOI: 10.7270/Q21N83VZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor (Homo sapiens (Human)) | BDBM50000214![]() (CHEMBL337862) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 63 | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Agonist activity at human alpha2a-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis | ACS Med Chem Lett 7: 956-961 (2016) Article DOI: 10.1021/acsmedchemlett.6b00290 BindingDB Entry DOI: 10.7270/Q2086784 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50000214![]() (CHEMBL337862) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 148 | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Agonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis | ACS Med Chem Lett 7: 956-961 (2016) Article DOI: 10.1021/acsmedchemlett.6b00290 BindingDB Entry DOI: 10.7270/Q2086784 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50000214![]() (CHEMBL337862) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development Curated by ChEMBL | Assay Description Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PL... | Bioorg Med Chem Lett 12: 471-5 (2002) Checked by Author BindingDB Entry DOI: 10.7270/Q22V2HD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic alpha1B (Homo sapiens (Human)) | BDBM50000214![]() (CHEMBL337862) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | n/a | <1.00E+5 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development Curated by ChEMBL | Assay Description Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled P... | Bioorg Med Chem Lett 12: 471-5 (2002) Checked by Author BindingDB Entry DOI: 10.7270/Q22V2HD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1D adrenergic receptor (Homo sapiens (Human)) | BDBM50000214![]() (CHEMBL337862) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | n/a | 794 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research and Development Curated by ChEMBL | Assay Description Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC ... | Bioorg Med Chem Lett 12: 471-5 (2002) Checked by Author BindingDB Entry DOI: 10.7270/Q22V2HD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2B adrenergic receptor (Homo sapiens (Human)) | BDBM50000214![]() (CHEMBL337862) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 955 | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Agonist activity at human alpha2b-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis | ACS Med Chem Lett 7: 956-961 (2016) Article DOI: 10.1021/acsmedchemlett.6b00290 BindingDB Entry DOI: 10.7270/Q2086784 | |||||||||||
More data for this Ligand-Target Pair |