BDBM50033887 CHEMBL3358611
SMILES: CC(C)(C)c1cc(CN(C(=O)CN(Cc2ccc(Cl)cc2)S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)c2ccc(C(O)=O)c(O)c2)cc(c1)C(C)(C)C
InChI Key: InChIKey=AMYVQFXKGYPZLQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transcription factor STAT5b (STAT5b) (Homo sapiens (Human)) | BDBM50033887 (CHEMBL3358611) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 146 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Mississauga Curated by ChEMBL | Assay Description Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay | ACS Med Chem Lett 5: 1202-1206 (2014) Article DOI: 10.1021/ml500165r BindingDB Entry DOI: 10.7270/Q25X2BJJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 3 (Homo sapiens (Human)) | BDBM50033887 (CHEMBL3358611) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.44E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Mississauga Curated by ChEMBL | Assay Description Inhibition of STAT3 (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay | ACS Med Chem Lett 5: 1202-1206 (2014) Article DOI: 10.1021/ml500165r BindingDB Entry DOI: 10.7270/Q25X2BJJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 3 (Homo sapiens (Human)) | BDBM50033887 (CHEMBL3358611) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 287 | n/a | n/a | n/a | n/a | n/a |
University of Toronto Mississauga Curated by ChEMBL | Assay Description Binding affinity to full-length His-tagged STAT3 (unknown origin) by surface plasmon resonance assay | ACS Med Chem Lett 5: 1202-1206 (2014) Article DOI: 10.1021/ml500165r BindingDB Entry DOI: 10.7270/Q25X2BJJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor STAT5b (STAT5b) (Homo sapiens (Human)) | BDBM50033887 (CHEMBL3358611) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a |
University of Toronto Mississauga Curated by ChEMBL | Assay Description Binding affinity to full-length His-tagged STAT5B (unknown origin) by surface plasmon resonance assay | ACS Med Chem Lett 5: 1202-1206 (2014) Article DOI: 10.1021/ml500165r BindingDB Entry DOI: 10.7270/Q25X2BJJ | |||||||||||
More data for this Ligand-Target Pair |