BDBM50039555 CHEMBL13130::[5-(6-Oxo-1,6-dihydro-purin-9-yl)-pentyl]-phosphonic acid
SMILES: OP(O)(=O)CCCCCn1cnc2c1nc[nH]c2=O
InChI Key: InChIKey=HKVZDTLGAPBOBY-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Purine-nucleoside phosphorylase (Rattus norvegicus) | BDBM50039555![]() (CHEMBL13130 | [5-(6-Oxo-1,6-dihydro-purin-9-yl)-pe...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Research Institute Curated by ChEMBL | Assay Description Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP) | J Med Chem 37: 2477-80 (1994) BindingDB Entry DOI: 10.7270/Q21G0K9T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50039555![]() (CHEMBL13130 | [5-(6-Oxo-1,6-dihydro-purin-9-yl)-pe...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ciba-Geigy Corporation Curated by ChEMBL | Assay Description Inhibition of human erythrocytic PNP (purine nucleoside phosphorylase) in 1 mM phosphate | J Med Chem 37: 1109-14 (1994) BindingDB Entry DOI: 10.7270/Q2348JFD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (Homo sapiens (Human)) | BDBM50039555![]() (CHEMBL13130 | [5-(6-Oxo-1,6-dihydro-purin-9-yl)-pe...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of Czech Republic Curated by ChEMBL | Assay Description Inhibition of human HGPRT | Bioorg Med Chem 20: 1076-89 (2012) Article DOI: 10.1016/j.bmc.2011.11.034 BindingDB Entry DOI: 10.7270/Q2RV0P44 | |||||||||||
More data for this Ligand-Target Pair |