BindingDB PrimarySearch

BDBM50055218 1-(2-naphthlmethyl) isatin-5-carboxamide::1-Naphthalen-2-ylmethyl-2,3-dioxo-2,3-dihydro-1H-indole-5-carboxylic acid amide::CHEMBL358279::med.21724, Compound 108

SMILES: NC(=O)c1ccc2N(Cc3ccc4ccccc4c3)C(=O)C(=O)c2c1

InChI Key: InChIKey=NTNYHMJYSGPGCQ-UHFFFAOYSA-N

Data: 1 KI 6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50055218
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Human rhinovirus A protease (Human rhinovirus B)	BDBM50055218 (1-(2-naphthlmethyl) isatin-5-carboxamide \| 1-Napht...) Show SMILES Show InChI	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human rhinovirus 3C protease				J Med Chem 39: 5072-82 (1997) Article DOI: 10.1021/jm960603e BindingDB Entry DOI: 10.7270/Q2K936MP
Agouron Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50055218 (1-(2-naphthlmethyl) isatin-5-carboxamide \| 1-Napht...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Beta-chymotrypsin (Homo sapiens (Human))	BDBM50055218 (1-(2-naphthlmethyl) isatin-5-carboxamide \| 1-Napht...) Show SMILES Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin				J Med Chem 49: 3440-3 (2006) Article DOI: 10.1021/jm0602357 BindingDB Entry DOI: 10.7270/Q2TD9WZX
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair
Papain (Carica papaya)	BDBM50055218 (1-(2-naphthlmethyl) isatin-5-carboxamide \| 1-Napht...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of papain				J Med Chem 49: 3440-3 (2006) Article DOI: 10.1021/jm0602357 BindingDB Entry DOI: 10.7270/Q2TD9WZX
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50055218 (1-(2-naphthlmethyl) isatin-5-carboxamide \| 1-Napht...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn					Assay Description This is a review article.				Med Res Rev (2020) Article DOI: 10.1002/med.21724 BindingDB Entry DOI: 10.7270/Q2JS9ST6
University of Bonn					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50055218 (1-(2-naphthlmethyl) isatin-5-carboxamide \| 1-Napht...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50055218 (1-(2-naphthlmethyl) isatin-5-carboxamide \| 1-Napht...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Trypsin (Homo sapiens (Human))	BDBM50055218 (1-(2-naphthlmethyl) isatin-5-carboxamide \| 1-Napht...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.52E+5	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of trypsin				J Med Chem 49: 3440-3 (2006) Article DOI: 10.1021/jm0602357 BindingDB Entry DOI: 10.7270/Q2TD9WZX
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair
Papain-like protease (PLpro) (Human SARS coronavirus (SARS-CoV))	BDBM50055218 (1-(2-naphthlmethyl) isatin-5-carboxamide \| 1-Napht...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of SARS CoV 3C-like protease				J Med Chem 49: 3440-3 (2006) Article DOI: 10.1021/jm0602357 BindingDB Entry DOI: 10.7270/Q2TD9WZX
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair
Human rhinovirus A protease (Human rhinovirus B)	BDBM50055218 (1-(2-naphthlmethyl) isatin-5-carboxamide \| 1-Napht...) Show SMILES Show InChI	MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of human rhinovirus 14 3C protease				J Med Chem 49: 3440-3 (2006) Article DOI: 10.1021/jm0602357 BindingDB Entry DOI: 10.7270/Q2TD9WZX
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair