null
SMILES: CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccncc2)cc1-c1ccccc1C)C([O-])=O
InChI Key: InChIKey=LHMOVHABFVYLCF-MHZLTWQESA-M
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50076802 (CHEMBL10912 | Lithium; (S)-2-{[2'-methyl-5-(5-pyri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase) | Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50076802 (CHEMBL10912 | Lithium; (S)-2-{[2'-methyl-5-(5-pyri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | >0.300 | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase) | Bioorg Med Chem Lett 9: 1069-74 (1999) BindingDB Entry DOI: 10.7270/Q2X34WNT | |||||||||||
More data for this Ligand-Target Pair |