BDBM50107997 6-[(2-Chloro-5-methyl-phenylamino)-methyl]-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL149273

SMILES: Cc1ccc(Cl)c(NCc2cnc3nc(N)nc(N)c3c2C)c1

InChI Key: InChIKey=YADRPZLGQLZNAM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50107997   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50107997 (6-[(2-Chloro-5-methyl-phenylamino)-methyl]-5-methy...) Show SMILES Cc1ccc(Cl)c(NCc2cnc3nc(N)nc(N)c3c2C)c1 Show InChI InChI=1S/C16H17ClN6/c1-8-3-4-11(17)12(5-8)20-6-10-7-21-15-13(9(10)2)14(18)22-16(19)23-15/h3-5,7,20H,6H2,1-2H3,(H4,18,19,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Lindsley F. Kimball Research Institute Curated by ChEMBL					Assay Description Antimycobacterial activity against human dihydrofolate reductase (hDHFR)				J Med Chem 45: 41-53 (2001) BindingDB Entry DOI: 10.7270/Q2FQ9VXR
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50107997 (6-[(2-Chloro-5-methyl-phenylamino)-methyl]-5-methy...) Show SMILES Cc1ccc(Cl)c(NCc2cnc3nc(N)nc(N)c3c2C)c1 Show InChI InChI=1S/C16H17ClN6/c1-8-3-4-11(17)12(5-8)20-6-10-7-21-15-13(9(10)2)14(18)22-16(19)23-15/h3-5,7,20H,6H2,1-2H3,(H4,18,19,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.950	n/a	n/a	n/a	n/a	n/a	n/a
Lindsley F. Kimball Research Institute Curated by ChEMBL					Assay Description Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR)				J Med Chem 45: 41-53 (2001) BindingDB Entry DOI: 10.7270/Q2FQ9VXR
					More data for this Ligand-Target Pair