BDBM50109383 1-(3-Phenyl-propyl)-4-pyridin-2-yl-piperazine::1-(3-phenylpropyl)-4-(pyridin-2-yl)piperazine::CHEMBL145867
SMILES: C(CN1CCN(CC1)c1ccccn1)Cc1ccccc1
InChI Key: InChIKey=QCVDHRLSVUSYNT-UHFFFAOYSA-N
Data: 7 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Sigma opioid receptor (RAT) | BDBM50109383 (1-(3-Phenyl-propyl)-4-pyridin-2-yl-piperazine | 1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 82 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Maryland Curated by ChEMBL | Assay Description Displacement of [3H](+)-pentazocine from sigma1 receptor in rat brain after 120 mins by liquid scintillation counting analysis | Bioorg Med Chem Lett 23: 6920-6922 (2013) Article DOI: 10.1016/j.bmcl.2013.09.038 BindingDB Entry DOI: 10.7270/Q2J969B5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50109383 (1-(3-Phenyl-propyl)-4-pyridin-2-yl-piperazine | 1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 83 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Maryland Curated by ChEMBL | Assay Description Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocine | Bioorg Med Chem Lett 12: 497-500 (2002) BindingDB Entry DOI: 10.7270/Q2CN7365 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50109383 (1-(3-Phenyl-propyl)-4-pyridin-2-yl-piperazine | 1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 83 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Maryland Curated by ChEMBL | Assay Description Displacement of [3H](+)-pentazocin from rat brain membrane sigma 1receptor after 120 mins | Bioorg Med Chem Lett 20: 2564-5 (2010) Article DOI: 10.1016/j.bmcl.2010.02.087 BindingDB Entry DOI: 10.7270/Q2833S6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50109383 (1-(3-Phenyl-propyl)-4-pyridin-2-yl-piperazine | 1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 940 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Maryland Curated by ChEMBL | Assay Description Displacement of [3H](-)-sulpiride from dopamine D2 receptor in rat brain after 120 mins by liquid scintillation counting analysis | Bioorg Med Chem Lett 23: 6920-6922 (2013) Article DOI: 10.1016/j.bmcl.2013.09.038 BindingDB Entry DOI: 10.7270/Q2J969B5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50109383 (1-(3-Phenyl-propyl)-4-pyridin-2-yl-piperazine | 1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Maryland Curated by ChEMBL | Assay Description Displacement of [3H]ketanserin from 5-HT2 receptor in rat brain after 120 mins by liquid scintillation counting analysis | Bioorg Med Chem Lett 23: 6920-6922 (2013) Article DOI: 10.1016/j.bmcl.2013.09.038 BindingDB Entry DOI: 10.7270/Q2J969B5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50109383 (1-(3-Phenyl-propyl)-4-pyridin-2-yl-piperazine | 1-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 9.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Maryland Curated by ChEMBL | Assay Description Displacement of [3H]WIN 35428 from dopamine transporter in rat striatum after 120 mins by liquid scintillation counting analysis | Bioorg Med Chem Lett 23: 6920-6922 (2013) Article DOI: 10.1016/j.bmcl.2013.09.038 BindingDB Entry DOI: 10.7270/Q2J969B5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50109383 (1-(3-Phenyl-propyl)-4-pyridin-2-yl-piperazine | 1-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Maryland Curated by ChEMBL | Assay Description Displacement of [3H]paroxetine from serotonin transporter in rat brainstem after 120 mins by liquid scintillation counting analysis | Bioorg Med Chem Lett 23: 6920-6922 (2013) Article DOI: 10.1016/j.bmcl.2013.09.038 BindingDB Entry DOI: 10.7270/Q2J969B5 | |||||||||||
More data for this Ligand-Target Pair |