BDBM50128384 (S)-1-[4-(6-Fluoro-benzo[b]thiophen-2-yl)-piperidin-1-yl]-3-(2-methyl-1H-indol-4-yloxy)-propan-2-ol::CHEMBL297742
SMILES: Cc1cc2c(OC[C@@H](O)CN3CCC(CC3)c3cc4ccc(F)cc4s3)cccc2[nH]1
InChI Key: InChIKey=BAWIIQXSRNFJHB-FQEVSTJZSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50128384 ((S)-1-[4-(6-Fluoro-benzo[b]thiophen-2-yl)-piperidi...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards serotonin [5-HT] reuptake site labeled with [3H]-paroxetine as radioligand | Bioorg Med Chem Lett 13: 1903-5 (2003) BindingDB Entry DOI: 10.7270/Q2PV6JR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50128384 ((S)-1-[4-(6-Fluoro-benzo[b]thiophen-2-yl)-piperidi...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Binding affinity was determined towards 5-hydroxytryptamine 1A receptor receptor using [3H]-8-OH-DPAT as radioligand | Bioorg Med Chem Lett 13: 1903-5 (2003) BindingDB Entry DOI: 10.7270/Q2PV6JR6 | |||||||||||
More data for this Ligand-Target Pair |