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BDBM50135927 7-(4-{4-[(S)-5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-benzoyl}-piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester::CHEMBL134040

SMILES: CCOC(=O)c1cn(CC)c2cc(N3CCN(CC3)C(=O)c3ccc(cc3F)N3C[C@H](CNC(C)=O)OC3=O)c(F)cc2c1=O

InChI Key: InChIKey=PYZGJDSIVMHJPO-FQEVSTJZSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50135927   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase II


(Homo sapiens (Human))		BDBM50135927
PNG
(7-(4-{4-[(S)-5-(Acetylamino-methyl)-2-oxo-oxazolid...)
Show SMILES CCOC(=O)c1cn(CC)c2cc(N3CCN(CC3)C(=O)c3ccc(cc3F)N3C[C@H](CNC(C)=O)OC3=O)c(F)cc2c1=O
Show InChI InChI=1S/C31H33F2N5O7/c1-4-35-17-23(30(42)44-5-2)28(40)22-13-25(33)27(14-26(22)35)36-8-10-37(11-9-36)29(41)21-7-6-19(12-24(21)32)38-16-20(45-31(38)43)15-34-18(3)39/h6-7,12-14,17,20H,4-5,8-11,15-16H2,1-3H3,(H,34,39)/t20-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.25E+4n/an/an/an/an/an/a



Vicuron Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli by Escherichia coli DNA gyrase gel-based supercoil assay

Bioorg Med Chem Lett 13: 4213-6 (2003)


BindingDB Entry DOI: 10.7270/Q2MP52PS
More data for this
Ligand-Target Pair