BDBM50151355 5-[1,8]Naphthyridin-4-yl-4-pyridin-2-yl-thiazol-2-ylamine::CHEMBL181958

SMILES: Nc1nc(c(s1)-c1ccnc2ncccc12)-c1ccccn1

InChI Key: InChIKey=PQGWZYBFJQPWRT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50151355   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50151355 (5-[1,8]Naphthyridin-4-yl-4-pyridin-2-yl-thiazol-2-...) Show SMILES Nc1nc(c(s1)-c1ccnc2ncccc12)-c1ccccn1 Show InChI InChI=1S/C16H11N5S/c17-16-21-13(12-5-1-2-7-18-12)14(22-16)10-6-9-20-15-11(10)4-3-8-19-15/h1-9H,(H2,17,21)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cells				J Med Chem 47: 4494-506 (2004) Article DOI: 10.1021/jm0400247 BindingDB Entry DOI: 10.7270/Q2VQ325T
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50151355 (5-[1,8]Naphthyridin-4-yl-4-pyridin-2-yl-thiazol-2-...) Show SMILES Nc1nc(c(s1)-c1ccnc2ncccc12)-c1ccccn1 Show InChI InChI=1S/C16H11N5S/c17-16-21-13(12-5-1-2-7-18-12)14(22-16)10-6-9-20-15-11(10)4-3-8-19-15/h1-9H,(H2,17,21)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (3.221-19.588)				J Med Chem 47: 4494-506 (2004) Article DOI: 10.1021/jm0400247 BindingDB Entry DOI: 10.7270/Q2VQ325T
					More data for this Ligand-Target Pair