null
SMILES: Brc1ccc(NC(=O)c2ccccn2)c(CN2C(=O)c3ccccc3C2=O)c1
InChI Key: InChIKey=JGXUCEXYUKMDKB-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50156082 (CHEMBL362969 | N-(4-bromo-2-((1,3-dioxoisoindolin-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a |
Merck& Co. Curated by ChEMBL | Assay Description Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assay | Bioorg Med Chem Lett 17: 1386-91 (2007) Article DOI: 10.1016/j.bmcl.2006.11.081 BindingDB Entry DOI: 10.7270/Q22V2GXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50156082 (CHEMBL362969 | N-(4-bromo-2-((1,3-dioxoisoindolin-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 750 | n/a | n/a | n/a | n/a |
Merck& Co. Curated by ChEMBL | Assay Description Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assay | Bioorg Med Chem Lett 17: 1386-91 (2007) Article DOI: 10.1016/j.bmcl.2006.11.081 BindingDB Entry DOI: 10.7270/Q22V2GXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50156082 (CHEMBL362969 | N-(4-bromo-2-((1,3-dioxoisoindolin-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 740 | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Effective concentration against metabotropic glutamate receptor 5 of human transfected into CHO cells | J Med Chem 47: 5825-8 (2004) Article DOI: 10.1021/jm049400d BindingDB Entry DOI: 10.7270/Q2HQ3ZC5 | |||||||||||
More data for this Ligand-Target Pair |