null

SMILES: Brc1ccc(NC(=O)c2ccccn2)c(CN2C(=O)c3ccccc3C2=O)c1

InChI Key: InChIKey=JGXUCEXYUKMDKB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50156082   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50156082 (CHEMBL362969 | N-(4-bromo-2-((1,3-dioxoisoindolin-...) Show SMILES Brc1ccc(NC(=O)c2ccccn2)c(CN2C(=O)c3ccccc3C2=O)c1 Show InChI InChI=1S/C21H14BrN3O3/c22-14-8-9-17(24-19(26)18-7-3-4-10-23-18)13(11-14)12-25-20(27)15-5-1-2-6-16(15)21(25)28/h1-11H,12H2,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Activity at rat mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assay				Bioorg Med Chem Lett 17: 1386-91 (2007) Article DOI: 10.1016/j.bmcl.2006.11.081 BindingDB Entry DOI: 10.7270/Q22V2GXH
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50156082 (CHEMBL362969 | N-(4-bromo-2-((1,3-dioxoisoindolin-...) Show SMILES Brc1ccc(NC(=O)c2ccccn2)c(CN2C(=O)c3ccccc3C2=O)c1 Show InChI InChI=1S/C21H14BrN3O3/c22-14-8-9-17(24-19(26)18-7-3-4-10-23-18)13(11-14)12-25-20(27)15-5-1-2-6-16(15)21(25)28/h1-11H,12H2,(H,24,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Activity at human mGluR5 expressed in CHO cells assessed as potentiation of glutamate response by FLIPR assay				Bioorg Med Chem Lett 17: 1386-91 (2007) Article DOI: 10.1016/j.bmcl.2006.11.081 BindingDB Entry DOI: 10.7270/Q22V2GXH
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50156082 (CHEMBL362969 | N-(4-bromo-2-((1,3-dioxoisoindolin-...) Show SMILES Brc1ccc(NC(=O)c2ccccn2)c(CN2C(=O)c3ccccc3C2=O)c1 Show InChI InChI=1S/C21H14BrN3O3/c22-14-8-9-17(24-19(26)18-7-3-4-10-23-18)13(11-14)12-25-20(27)15-5-1-2-6-16(15)21(25)28/h1-11H,12H2,(H,24,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	740	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Effective concentration against metabotropic glutamate receptor 5 of human transfected into CHO cells				J Med Chem 47: 5825-8 (2004) Article DOI: 10.1021/jm049400d BindingDB Entry DOI: 10.7270/Q2HQ3ZC5
					More data for this Ligand-Target Pair