US11028064, Example 51 N-Cyclopentyl-3-(5-((5-(2-(dimethylamino)ethoxy)-7-methyl-9-oxo-9H-thioxanthen-3-yl)oxy)pyridin-2-yl)propanamide

SMILES: CN(C)CCOc1cc(C)cc2c1sc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O

InChI Key: InChIKey=LNZZOAVXCFMVNJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 501737   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM501737 (N-Cyclopentyl-3-(5-((5-(2-(dimethylamino)ethoxy)-7...) Show SMILES CN(C)CCOc1cc(C)cc2c1sc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O Show InChI InChI=1S/C31H35N3O4S/c1-20-16-26-30(36)25-12-11-23(18-28(25)39-31(26)27(17-20)37-15-14-34(2)3)38-24-10-8-21(32-19-24)9-13-29(35)33-22-6-4-5-7-22/h8,10-12,16-19,22H,4-7,9,13-15H2,1-3H3,(H,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AUCKLAND UNISERVICES LIMITED US Patent									US Patent US11028064 (2021)
					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM501737 (N-Cyclopentyl-3-(5-((5-(2-(dimethylamino)ethoxy)-7...) Show SMILES CN(C)CCOc1cc(C)cc2c1sc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O Show InChI InChI=1S/C31H35N3O4S/c1-20-16-26-30(36)25-12-11-23(18-28(25)39-31(26)27(17-20)37-15-14-34(2)3)38-24-10-8-21(32-19-24)9-13-29(35)33-22-6-4-5-7-22/h8,10-12,16-19,22H,4-7,9,13-15H2,1-3H3,(H,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
AUCKLAND UNISERVICES LIMITED US Patent					Assay Description IC50 values were determined using the Z′-LYTE® activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...				US Patent US11028064 (2021)
					More data for this Ligand-Target Pair